Biocompatible Poly(N-isopropylacrylamide)-halloysite Nanotubes for Thermoresponsive Curcumin Release

被引:57
作者
Cavallaro, Giuseppe [1 ]
Lazzara, Giuseppe [1 ]
Massaro, Marina [2 ]
Milioto, Stefana [1 ]
Noto, Renato [2 ]
Parisi, Filippo [1 ]
Riela, Serena [2 ]
机构
[1] Univ Palermo, Dipartimento Fis & Chim, Via Sci,Ed 17, I-90128 Palermo, Italy
[2] Univ Palermo, Dipartimento STEBICEF, Sez Chim, I-90128 Palermo, Italy
关键词
HALLOYSITE CLAY NANOTUBES; SUSTAINED-RELEASE; TUMOR-GROWTH; WATER; CYCLODEXTRIN; STABILITY; KINETICS; BRUSHES; AGENTS; LUMEN;
D O I
10.1021/acs.jpcc.5b00991
中图分类号
O64 [物理化学(理论化学)、化学物理学];
学科分类号
070304 ; 081704 ;
摘要
The grafting of poly(N-isopropylacrylamide) (PNIPAAM) onto the halloysite external surface is proposed in order to obtain a novel thermoresponsive drug carrier for curcumin delivery. The new nanomaterial is characterized by means of FT-IR spectroscopy, thermogravimetric analysis, and SEM investigations. A high density of polymer,chain was achieved at the nanoparticle surface. The PNIPAAM dehydration phenomenon was observed in water above 32 degrees C that is nearly coincident-with the lower critical solution temperature for the polymer. The colloidal stability as well as the wettability of the obtained nanomaterial may be triggered by temperature stimuli. In vitro tests simulating the gastrointestinal transit demonstrated that the proposed delivery System allows a targeted release of curcumin, preventing its degradation in an acidic medium. We synthesized a new hybrid nanoparticle that is very promising for several applications due to the copresence of a biocompatible region, to the temperature response, and to the hollow cavity, which can load active species.
引用
收藏
页码:8944 / 8951
页数:8
相关论文
共 46 条
[1]   Enlargement of Halloysite Clay Nanotube Lumen by Selective Etching of Aluminum Oxide [J].
Abdullayev, Elshad ;
Joshi, Anupam ;
Wei, Wenbo ;
Zhao, Yafei ;
Lvov, Yuri .
ACS NANO, 2012, 6 (08) :7216-7226
[2]   Natural Tubule Clay Template Synthesis of Silver Nanorods for Antibacterial Composite Coating [J].
Abdullayev, Elshad ;
Sakakibara, Keita ;
Okamoto, Ken ;
Wei, Wenbo ;
Ariga, Katsuhiko ;
Lvov, Yuri .
ACS APPLIED MATERIALS & INTERFACES, 2011, 3 (10) :4040-4046
[3]   Clay nanotubes for corrosion inhibitor encapsulation: release control with end stoppers [J].
Abdullayev, Elshad ;
Lvov, Yuri .
JOURNAL OF MATERIALS CHEMISTRY, 2010, 20 (32) :6681-6687
[4]   Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IκBα kinase and Akt activation [J].
Aggarwal, S ;
Ichikawa, H ;
Takada, Y ;
Sandur, SK ;
Shishodia, S ;
Aggarwal, BB .
MOLECULAR PHARMACOLOGY, 2006, 69 (01) :195-206
[5]   Bioavailability of curcumin: Problems and promises [J].
Anand, Preetha ;
Kunnumakkara, Ajaikumar B. ;
Newman, Robert A. ;
Aggarwal, Bharat B. .
MOLECULAR PHARMACEUTICS, 2007, 4 (06) :807-818
[6]   Amino acid derivatives of beta-cyclodextrin [J].
Ashton, PR ;
Koniger, R ;
Stoddart, JF ;
Alker, D ;
Harding, VD .
JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (03) :903-908
[7]   A structural definition of polymer brushes [J].
Brittain, William J. ;
Minko, Sergiy .
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2007, 45 (16) :3505-3512
[8]   Halloysite nanotube with fluorinated lumen: Non-foaming nanocontainer for storage and controlled release of oxygen in aqueous media [J].
Cavallaro, Giuseppe ;
Lazzara, Giuseppe ;
Milioto, Stefana ;
Palmisano, Giovanni ;
Parisi, Filippo .
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2014, 417 :66-71
[9]   Modified Halloysite Nanotubes: Nanoarchitectures for Enhancing the Capture of Oils from Vapor and Liquid Phases [J].
Cavallaro, Giuseppe ;
Lazzara, Giuseppe ;
Milioto, Stefana ;
Parisi, Filippo ;
Sanzillo, Vincenzo .
ACS APPLIED MATERIALS & INTERFACES, 2014, 6 (01) :606-612
[10]   Exploiting the Colloidal Stability and Solubilization Ability of Clay Nanotubes/Ionic Surfactant Hybrid Nanomaterials [J].
Cavallaro, Giuseppe ;
Lazzara, Giuseppe ;
Milioto, Stefana .
JOURNAL OF PHYSICAL CHEMISTRY C, 2012, 116 (41) :21932-21938