Anticancer potential of indole derivatives: an update

被引：0

作者：

Misra, Shashi Kiran ^{[2
]}

Pathak, Devender ^{[1
]}

Pathak, Kamla ^{[1
]}

机构：

[1] Uttar Pradesh Univ Med Sci, Fac Pharm, Etawah 206130, Uttar Pradesh, India

[2] Chhatrapati Shahu Ji Maharaj Univ, Univ Inst Pharm, Kanpur 208026, Uttar Pradesh, India

来源：

PHYSICAL SCIENCES REVIEWS | 2021年

关键词：

anticancer agents; heterocyclic; indole derivatives; receptors; HISTONE DEACETYLASE INHIBITORS; BREAST-CANCER CELLS; DNA CROSS-LINKING; IN-VITRO; ANTITUMOR-ACTIVITY; SIGNALING PATHWAYS; AGENTS; INDOLE-3-CARBINOL; APOPTOSIS; ALKALOIDS;

D O I：

10.1515/psr-2021-0028

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The heterocyclic indole is one of the most prevalent pharmacophores in nature. It has been a highly privileged scaffold for designing targeted and anticancer therapeutics. Countless fused heterocyclic templates have been developed with diverse physicochemical and biological properties. Due to their versatile ethanobotanical and pharmacological values, indole and its derivatives seek high demand in the chemical and healthcare sectors. Extensive anticancer research has been conducted in this decade to evaluate their efficacy for diverse malignancies. The chapter explores the anticancer activity of natural and synthetic indole derivatives expressed through targeting different biological receptors and enzymes.

引用

页码：1545 / 1569

页数：25

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