Anticancer potential of indole derivatives: an update

被引：0

作者：

Misra, Shashi Kiran ^{[2
]}

Pathak, Devender ^{[1
]}

Pathak, Kamla ^{[1
]}

机构：

[1] Uttar Pradesh Univ Med Sci, Fac Pharm, Etawah 206130, Uttar Pradesh, India

[2] Chhatrapati Shahu Ji Maharaj Univ, Univ Inst Pharm, Kanpur 208026, Uttar Pradesh, India

来源：

PHYSICAL SCIENCES REVIEWS | 2021年

关键词：

anticancer agents; heterocyclic; indole derivatives; receptors; HISTONE DEACETYLASE INHIBITORS; BREAST-CANCER CELLS; DNA CROSS-LINKING; IN-VITRO; ANTITUMOR-ACTIVITY; SIGNALING PATHWAYS; AGENTS; INDOLE-3-CARBINOL; APOPTOSIS; ALKALOIDS;

D O I：

10.1515/psr-2021-0028

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The heterocyclic indole is one of the most prevalent pharmacophores in nature. It has been a highly privileged scaffold for designing targeted and anticancer therapeutics. Countless fused heterocyclic templates have been developed with diverse physicochemical and biological properties. Due to their versatile ethanobotanical and pharmacological values, indole and its derivatives seek high demand in the chemical and healthcare sectors. Extensive anticancer research has been conducted in this decade to evaluate their efficacy for diverse malignancies. The chapter explores the anticancer activity of natural and synthetic indole derivatives expressed through targeting different biological receptors and enzymes.

引用

页码：1545 / 1569

页数：25

共 50 条

[1] INDOLE DERIVATIVES AS POTENTIAL ANTICANCER AGENTS: A REVIEW
Sachdeva, Harshita
Mathur, Jaya
Guleria, Anjali
JOURNAL OF THE CHILEAN CHEMICAL SOCIETY, 2020, 65 (03): : 4900 - 4907
[2] Coumarin derivatives with anticancer activities: An update
Song Xu-Feng
Fan Jing
Liu Lan
Liu Xiao-Feng
Gao Feng
ARCHIV DER PHARMAZIE, 2020, 353 (08)
[3] Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents
Hong, Yu
Zhu, Yuan-Yuan
He, Qiuqin
Gu, Shuang-Xi
BIOORGANIC & MEDICINAL CHEMISTRY, 2022, 55
[4] Indole derivatives targeting colchicine binding site as potential anticancer agents
Goel, Bharat
Jaiswal, Shivani
Jain, Shreyans K. K.
ARCHIV DER PHARMAZIE, 2023, 356 (10)
[5] Anticancer Potential of Biologically Active Diosgenin and its Derivatives: An Update
Mondal, Sadhan
CURRENT TRADITIONAL MEDICINE, 2024, 10 (01) : 67 - 80
[6] Novel indole derivatives as potential anticancer agents: Design, synthesis and biological screening
Prakash, B.
Amuthavalli, A.
Edison, D.
Sivaramkumar, M. S.
Velmurugan, R.
MEDICINAL CHEMISTRY RESEARCH, 2018, 27 (01) : 321 - 331
[7] Design, Synthesis, and Anticancer Evaluation of Novel Indole Derivatives of Ursolic Acid as Potential Topoisomerase II Inhibitors
Li, A-Liang
Hao, Yun
Wang, Wen-Yan
Liu, Qing-Song
Sun, Yue
Gu, Wen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (08)
[8] Molecular targets and anticancer potential of indole-3-carbinol and its derivatives
Aggarwal, BB
Ichikawa, H
CELL CYCLE, 2005, 4 (09) : 1201 - 1215
[9] Synthesis and Anticancer Activity of Indole-Functionalized Derivatives of Betulin
Rzepka, Zuzanna
Bebenek, Ewa
Chrobak, Elwira
Wrzesniok, Dorota
PHARMACEUTICS, 2022, 14 (11)
[10] Recent Development in Indole Derivatives as Anticancer Agents for Breast Cancer
Kaur, Kamalprect
Jaitak, Vikas
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2019, 19 (08) : 962 - 983

← 1 2 3 4 5 →