Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mech-anisms

被引:23
作者
Chen, Xing-Dong [1 ,2 ]
Tang, Jun-Jie [2 ]
Feng, Shuang [2 ]
Huang, Hua [2 ]
Lu, Feng-Nian [3 ]
Lu, Xiu-Min [2 ]
Wang, Yong-Tang [1 ]
机构
[1] Army Med Univ, Daping Hosp, State Key Lab Trauma Burns & Combined Injury, Chongqing 400042, Peoples R China
[2] Chongqing Univ Technol, Coll Pharm & Bioengn, Chongqing 400054, Peoples R China
[3] Shandong Univ Tradit Chinese Med, Coll Pharmaceut Sci, Jinan 250355, Peoples R China
基金
中国国家自然科学基金;
关键词
Chlorogenic acid; post-traumatic stress disorder; PTSD-like symptoms; learning and memory; apoptosis; oxidative stress; OXIDATIVE STRESS; TARGETS; COFFEE; IMPAIRMENT; VITAGENES; DAMAGE; LIVER; RATS;
D O I
10.2174/1570159X19666210111155110
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Chlorogenic acid (CGA) is a kind of traditional Chinese medicine, abundant in honey-suckle and eucommia, and has a wide range of biological activities, and pharmacological effects. Previous studies have shown that CGA can regulate learning, memory, cognitive ability, coupled with improvement to anxiety, depression, and other post-traumatic stress disorder (PTSD)-like symptoms. This article explores the protective effects of CGA on neurons through its anti-apoptot-ic effect, inhibition of neuroinflammation and oxidative stress, which may be the mechanisms of its improvement of PTSD-like symptoms. It may provide a new therapeutic strategy for the treat-ment of PTSD and its comorbidities.
引用
收藏
页码:2180 / 2187
页数:8
相关论文
共 67 条
[1]   The Neurobiology and Pharmacotherapy of Posttraumatic Stress Disorder [J].
Abdallah, Chadi G. ;
Averill, Lynnette A. ;
Akiki, Teddy J. ;
Raza, Mohsin ;
Averill, Christopher L. ;
Gomaa, Hassaan ;
Adikey, Archana ;
Krystal, John H. .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59, 2019, 59 :171-189
[2]   Investigating Individual Pre-trauma Susceptibility to a PTSD-Like Phenotype in Animals [J].
Alexander, Khadijah S. ;
Nalloor, Rebecca ;
Bunting, Kristopher M. ;
Vazdarjanova, Almira .
FRONTIERS IN SYSTEMS NEUROSCIENCE, 2020, 13
[3]   Chlorogenic Acid Attenuates Kidney Ischemic/Reperfusion Injury via Reducing Inflammation, Tubular Injury, and Myofibroblast Formation [J].
Arfian, Nur ;
Wahyudi, Danny A. P. ;
Zulfatina, Ingesti B. ;
Citta, Arsitya N. ;
Anggorowati, Nungki ;
Multazam, Ali ;
Romi, Muhammad M. ;
Sari, Dwi C. R. .
BIOMED RESEARCH INTERNATIONAL, 2019, 2019
[4]   In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile [J].
Bagdas, Deniz ;
Etoz, Betul Cam ;
Gul, Zulfiye ;
Ziyanok, Sedef ;
Inan, Sevda ;
Turacozen, Ozge ;
Gul, Nihal Yasar ;
Topal, Ayse ;
Cinkilic, Nilufer ;
Tas, Sibel ;
Ozyigit, Musa Ozgur ;
Gurun, Mine Sibel .
FOOD AND CHEMICAL TOXICOLOGY, 2015, 81 :54-61
[5]   The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease [J].
Barres, Ben A. .
NEURON, 2008, 60 (03) :430-440
[6]   Chlorogenic acid attenuates high-carbohydrate, high-fat diet-induced cardiovascular, liver, and metabolic changes in rats [J].
Bhandarkar, Nikhil S. ;
Brown, Lindsay ;
Panchal, Sunil K. .
NUTRITION RESEARCH, 2019, 62 :78-88
[7]   Chlorogenic Acid Potentiates the Anti-Inflammatory Activity of Curcumin in LPS-Stimulated THP-1 Cells [J].
Bisht, Akshay ;
Dickens, Martin ;
Rutherfurd-Markwick, Kay ;
Thota, Rohith ;
Mutukumira, Anthony N. ;
Singh, Harjinder .
NUTRIENTS, 2020, 12 (09) :1-12
[8]   Chlorogenic acid, a polyphenol from Prunus domestica (Mirabelle), with coupled anxiolytic and antioxidant effects [J].
Bouayed, Jaouad ;
Rammal, Hassan ;
Dicko, Amadou ;
Younos, Chafique ;
Soulimani, Rachid .
JOURNAL OF THE NEUROLOGICAL SCIENCES, 2007, 262 (1-2) :77-84
[9]   Healthspan Maintenance and Prevention of Parkinson's-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans [J].
Brunetti, Giovanni ;
Di Rosa, Gabriele ;
Scuto, Maria ;
Leri, Manuela ;
Stefani, Massimo ;
Schmitz-Linneweber, Christian ;
Calabrese, Vittorio ;
Saul, Nadine .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (07)
[10]   Aging and Parkinson's Disease: Inflammaging, neuroinflammation and biological remodeling as key factors in pathogenesis [J].
Calabrese, Vittorio ;
Santoro, Aurelia ;
Monti, Daniela ;
Crupi, Rosalia ;
Di Paola, Rosanna ;
Latteri, Saverio ;
Cuzzocrea, Salvatore ;
Zappia, Mario ;
Giordano, James ;
Calabrese, Edward J. ;
Franceschi, Claudio .
FREE RADICAL BIOLOGY AND MEDICINE, 2018, 115 :80-91