Chlorogenic Acid Improves PTSD-like Symptoms and Associated Mech-anisms

被引：23

作者：

Chen, Xing-Dong ^{[1
,2
]}

Tang, Jun-Jie ^{[2
]}

Feng, Shuang ^{[2
]}

Huang, Hua ^{[2
]}

Lu, Feng-Nian ^{[3
]}

Lu, Xiu-Min ^{[2
]}

Wang, Yong-Tang ^{[1
]}

机构：

[1] Army Med Univ, Daping Hosp, State Key Lab Trauma Burns & Combined Injury, Chongqing 400042, Peoples R China

[2] Chongqing Univ Technol, Coll Pharm & Bioengn, Chongqing 400054, Peoples R China

[3] Shandong Univ Tradit Chinese Med, Coll Pharmaceut Sci, Jinan 250355, Peoples R China

来源：

CURRENT NEUROPHARMACOLOGY | 2021年 / 19卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Chlorogenic acid; post-traumatic stress disorder; PTSD-like symptoms; learning and memory; apoptosis; oxidative stress; OXIDATIVE STRESS; TARGETS; COFFEE; IMPAIRMENT; VITAGENES; DAMAGE; LIVER; RATS;

D O I：

10.2174/1570159X19666210111155110

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Chlorogenic acid (CGA) is a kind of traditional Chinese medicine, abundant in honey-suckle and eucommia, and has a wide range of biological activities, and pharmacological effects. Previous studies have shown that CGA can regulate learning, memory, cognitive ability, coupled with improvement to anxiety, depression, and other post-traumatic stress disorder (PTSD)-like symptoms. This article explores the protective effects of CGA on neurons through its anti-apoptot-ic effect, inhibition of neuroinflammation and oxidative stress, which may be the mechanisms of its improvement of PTSD-like symptoms. It may provide a new therapeutic strategy for the treat-ment of PTSD and its comorbidities.

引用

页码：2180 / 2187

页数：8

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