The state of vaccine safety science: systematic reviews of the evidence

被引：76

作者：

Dudley, Matthew Z. ^{[1
,2
]}

Halsey, Neal A. ^{[1
,2
,6
]}

Omer, Saad B. ^{[12
,13
]}

Orenstein, Walter A. ^{[10
,11
]}

O'Leary, Sean T. ^{[7
,8
,9
]}

Limaye, Rupali J. ^{[1
,2
,3
,4
,5
]}

Salmon, Daniel A. ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Univ, Dept Int Hlth, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Inst Vaccine Safety, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Dept Hlth Behav & Soc, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Dept Epidemiol, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Int Vaccine Access Ctr, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD 21205 USA

[6] Johns Hopkins Univ, Sch Med, Dept Pediat, Baltimore, MD 21205 USA

[7] Univ Colorado, Anschutz Med Campus, Adult & Child Consortium Hlth Outcomes Res & Deli, Aurora, CO USA

[8] Univ Colorado, Anschutz Med Campus, Dept Pediat, Aurora, CO USA

[9] Univ Colorado, Childrens Hosp, Aurora, CO USA

[10] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA 30322 USA

[11] Emory Univ, Sch Med, Emory Vaccine Ctr, Atlanta, GA 30322 USA

[12] Yale Sch Publ Hlth, Epidemiol Microbial Dis, Yale Sch Global Hlth, New Haven, CT USA

[13] Yale Sch Med, New Haven, CT USA

来源：

LANCET INFECTIOUS DISEASES | 2020年 / 20卷 / 05期

基金：

美国国家卫生研究院;

关键词：

GUILLAIN-BARRE-SYNDROME; IMMUNE THROMBOCYTOPENIC PURPURA; UNITED-STATES; CHILDHOOD VACCINES; IMMUNIZATION; CHILDREN; PARENTS; RISK; ASSOCIATION; PERTUSSIS;

D O I：

10.1016/S1473-3099(20)30130-4

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

This Review updates the scientific evidence assessing possible causal associations of adverse events following immunisation (AEFI) compiled in the 2012 report from the Institute of Medicine and the 2014 report from the Agency for Healthcare Research and Quality. For 12 of 46 AEFI examined, a causal relationship has been established with at least one vaccine currently routinely recommended to the general USA population: anaphylaxis, arthralgia or arthritis (mild, acute, and transient, not chronic), deltoid bursitis (when vaccine is administered improperly), disseminated varicella infection (in immune deficient individuals for whom the varicella vaccine is contraindicated), encephalitis, febrile seizures, Guillain-Barre syndrome, hepatitis (in immune deficient individuals for whom the varicella vaccine is contraindicated), herpes zoster, immune thrombocytopenic purpura, meningitis, and syncope. Other than mild acute and transient arthralgia or arthritis, which is very common in adult women after rubella vaccine, these adverse reactions are rare or very rare. Vaccines have an excellent safety profile overall and provide protection against infectious diseases to individuals and the general population.

引用

页码：E80 / E89

页数：10

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