SARS-CoV-2 T Cell Responses Elicited by COVID-19 Vaccines or Infection Are Expected to Remain Robust against Omicron

被引：62

作者：

Ahmed, Syed Faraz ^{[1
]}

Quadeer, Ahmed Abdul ^{[1
]}

McKay, Matthew R. ^{[1
,2
,3
,4
]}

机构：

[1] Hong Kong Univ Sci & Technol, Dept Elect & Comp Engn, Hong Kong, Peoples R China

[2] Hong Kong Univ Sci & Technol, Dept Chem & Biol Engn, Hong Kong, Peoples R China

[3] Univ Melbourne, Dept Elect & Elect Engn, Parkville, Vic 3010, Australia

[4] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Parkville, Vic 3000, Australia

来源：

VIRUSES-BASEL | 2022年 / 14卷 / 01期

关键词：

SARS-CoV-2; COVID-19; Omicron; variants; T cell epitopes; mutations; insertions; deletions; peptide-HLA binding;

D O I：

10.3390/v14010079

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Omicron, the most recent SARS-CoV-2 variant of concern (VOC), harbours multiple mutations in the spike protein that were not observed in previous VOCs. Initial studies suggest Omicron to substantially reduce the neutralizing capability of antibodies induced from vaccines and previous infection. However, its effect on T cell responses remains to be determined. Here, we assess the effect of Omicron mutations on known T cell epitopes and report data suggesting T cell responses to remain broadly robust against this new variant.

引用

页数：6

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