The Function of cGAS-STING Pathway in Treatment of Pancreatic Cancer

被引：21

作者：

Mohseni, Ghazal ^{[1
,2
]}

Li, Juan ^{[1
]}

Ariston Gabriel, Abakundana Nsenga ^{[1
,2
]}

Du, Lutao ^{[1
]}

Wang, Yun-shan ^{[1
]}

Wang, Chuanxin ^{[1
]}

机构：

[1] Shandong Univ, Hosp 2, Cheeloo Coll Med, Dept Clin Lab, Jinan, Peoples R China

[2] Shandong Univ, Cheeloo Coll Med, Sch Med, Dept Clin Lab Diagnost, Jinan, Peoples R China

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

pancreatic cancer; cGAS-STING pathway; immunotherapy; type I interferon (IFN); cytosolic DNA; CELL-DEATH; T-CELLS; CYCLIC DINUCLEOTIDE; ANTITUMOR IMMUNITY; I INTERFERONS; FERROPTOSIS; RECOGNITION; ACTIVATION; EXPRESSION; INFECTION;

D O I：

10.3389/fimmu.2021.781032

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The activation of stimulator of interferon genes (STING) signalling pathway has been suggested to promote the immune responses against malignancy. STING is activated in response to the detection of cytosolic DNA and can induce type I interferons and link innate immunity with the adaptive immune system. Due to accretive evidence demonstrating that the STING pathway regulates the immune cells of the tumor microenvironment (TME), STING as a cancer biotherapy has attracted considerable attention. Pancreatic cancer, with a highly immunosuppressive TME, remains fatal cancer. STING has been applied to the treatment of pancreatic cancer through distinct strategies. This review reveals the role of STING signalling on pancreatic tumors and other diseases related to the pancreas. We then discuss new advances of STING in either monotherapy or combination methods for pancreatic cancer immunotherapy.

引用

页数：10

共 98 条

[1] cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING [J].

Ablasser, Andrea ;

Goldeck, Marion ;

Cavlar, Taner ;

Deimling, Tobias ;

Witte, Gregor ;

Roehl, Ingo ;

Hopfner, Karl-Peter ;

Ludwig, Janos ;

Hornung, Veit .

NATURE, 2013, 498 (7454) :380-+

[2] High potency STING agonists engage unique myeloid pathways to reverse pancreatic cancer immune privilege [J].

Ager, Casey R. ;

Boda, Akash ;

Rajapakshe, Kimal ;

Lea, Spencer Thomas ;

Di Francesco, Maria Emilia ;

Jayaprakash, Priyamvada ;

Slay, Ravaen B. ;

Morrow, Brittany ;

Prasad, Rishika ;

Dean, Meghan A. ;

Duffy, Colm R. ;

Coarfa, Cristian ;

Jones, Philip ;

Curran, Michael A. .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 (08)

[3] Diverse roles of STING-dependent signaling on the development of cancer [J].

Ahn, J. ;

Konno, H. ;

Barber, G. N. .

ONCOGENE, 2015, 34 (41) :5302-5308

[4] Inflammation-driven carcinogenesis is mediated through STING [J].

Ahn, Jeonghyun ;

Xia, Tianli ;

Konno, Hiroyasu ;

Konno, Keiko ;

Ruiz, Phillip ;

Barber, Glen N. .

NATURE COMMUNICATIONS, 2014, 5

[5] Deficiency of the innate immune adaptor STING promotes autoreactive T cell expansion in NOD mice [J].

Akazawa, Satoru ;

Mackin, Leanne ;

Jhala, Gaurang ;

Fynch, Stacey ;

Catterall, Tara ;

Selck, Claudia ;

Graham, Kate L. ;

Krishnamurthy, Balasubramanian ;

Pappas, Evan G. ;

Kwong, Chun-Ting J. ;

Sutherland, Andrew P. R. ;

Kay, Thomas W. H. ;

Brodnicki, Thomas C. ;

Thomas, Helen E. .

DIABETOLOGIA, 2021, 64 (04) :878-889

[6] Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors [J].

Baird, Jason R. ;

Friedman, David ;

Cottam, Benjamin ;

Dubensky, Thomas W., Jr. ;

Kanne, David B. ;

Bambina, Shelly ;

Bahjat, Keith ;

Crittenden, Marka R. ;

Gough, Michael J. .

CANCER RESEARCH, 2016, 76 (01) :50-61

[7] Challenges and Opportunities for Pancreatic Cancer Immunotherapy [J].

Bear, Adham S. ;

Vonderheide, Robert H. ;

O'Hara, Mark H. .

CANCER CELL, 2020, 38 (06) :788-802

[8] Influence of type-I Interferon receptor expression level on the response to type-I Interferons in human pancreatic cancer cells [J].

Booy, Stephanie ;

van Eijck, Casper H. J. ;

Dogan, Fadime ;

van Koetsveld, Peter M. ;

Hofland, Leo J. .

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2014, 18 (03) :492-502

[9] Intracellular Nucleic Acid Sensing Triggers Necroptosis through Synergistic Type I IFN and TNF Signaling [J].

Brault, Michelle ;

Olsen, Tayla M. ;

Martinez, Jennifer ;

Stetson, Daniel B. ;

Oberst, Andrew .

JOURNAL OF IMMUNOLOGY, 2018, 200 (08) :2748-2756

[10] Cancer vaccines [J].

Butterfield, Lisa H. .

BMJ-BRITISH MEDICAL JOURNAL, 2015, 350

← 1 2 3 4 5 6 7 8 9 10 →