Rat BodyMap transcriptomes reveal unique circular RNA features across tissue types and developmental stages

被引：55

作者：

Zhou, Tong ^{[1
]}

Xie, Xueying ^{[2
]}

Li, Musheng ^{[2
]}

Shi, Junchao ^{[1
]}

Zhou, Jin J. ^{[3
]}

Knox, Kenneth S. ^{[4
]}

Wang, Ting ^{[4
]}

Chen, Qi ^{[1
]}

Gu, Wanjun ^{[2
]}

机构：

[1] Univ Nevada, Reno Sch Med, Dept Physiol & Cell Biol, Reno, NV 89557 USA

[2] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China

[3] Univ Arizona, Dept Epidemiol & Biostat, Tucson, AZ 85721 USA

[4] Univ Arizona, Coll Med Phoenix, Dept Internal Med, Phoenix, AZ 85004 USA

来源：

RNA | 2018年 / 24卷 / 11期

基金：

中国国家自然科学基金;

关键词：

circRNA expression; testis function; tissue specificity; age-dependent expression; EXON CIRCULARIZATION; EXPRESSION; CIRCRNAS; BRAIN; IDENTIFICATION; ACCUMULATION; TRANSLATION; BIOGENESIS; ENRICHMENT; EFFICIENT;

D O I：

10.1261/rna.067132.118

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Circular RNAs (circRNAs) are a novel class of regulatory RNAs. Here, we present a comprehensive investigation of circRNA expression profiles across 11 tissues and four developmental stages in rats, along with cross-species analyses in humans and mice. Although the expression of circRNAs is positively correlated with that of cognate mRNAs, highly expressed genes tend to splice a larger fraction of circular transcripts. Moreover, circRNAs exhibit higher tissue specificity than cognate mRNAs. Intriguingly, while we observed a monotonic increase of circRNA abundance with age in the rat brain, we further discovered a dynamic, age-dependent pattern of circRNA expression in the testes that is characterized by a dramatic increase with advancing stages of sexual maturity and a decrease with aging. The age-sensitive testicular circRNAs are highly associated with spermatogenesis, independent of cognate mRNA expression. The tissue/age implications of circRNAs suggest that they present unique physiological functions rather than simply occurring as occasional by-products of gene transcription.

引用

页码：1443 / 1456

页数：14

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