Regulation of phagocytosis by Rho GTPases

Phagocytosis is the mechanism of internalization used by specialized cells such as macrophages, dendritic cells, and neutrophils to internalize, degrade, and eventually present peptides derived from particulate antigens. The phagocytic process comprises several sequential and complex events initiated by the recognition of ligands on the surface of the particles by specific receptors on the surface of the phagocytic cells. Receptor clustering at the attachment site generates a phagocytic signal that in turn leads to local polymerization of actin filaments and to particle internalization. Depending on the particles and receptors involved, it appears that the structures and mechanisms associated with particle ingestion are diverse. However, work during the past few years has highlighted the importance of small GTP-binding proteins of the Rho family in various types of phagocytosis. As reviewed here, Rho family GTPases, their activators, and their downstream effectors control the local reorganization of the actin cytoskeleton beneath bound particles.