Limbus Damage in Ocular Graft-versus-Host Disease

被引：27

作者：

Lorenzo Perez, Rebeca ^{[1
]}

Perez-Simon, Jose A. ^{[2
,5
]}

Caballero-Velazquez, Teresa ^{[2
]}

Flores, Teresa ^{[3
]}

Carrancio, Soraya ^{[2
]}

Herrero, Carmen ^{[2
]}

Blanco, Belen ^{[2
]}

Gutierrez-Cosio, Silvia ^{[2
]}

Canete-Campos, Cristina ^{[1
]}

Cruz Gonzalez, Fernando ^{[1
]}

San-Miguel, Jesus F. ^{[2
,4
,5
,6
]}

Hernandez-Galilea, Emiliano ^{[1
]}

Sanchez-Abarca, Ignacio ^{[2
,4
,5
]}

机构：

[1] Hosp Univ Salamanca, Serv Oftalmol, Salamanca, Spain

[2] Hosp Univ Salamanca, Serv Hematol, Salamanca, Spain

[3] Hosp Univ Salamanca, Serv Anat Patol, Salamanca, Spain

[4] Univ Salamanca, Ctr Invest Canc, E-37008 Salamanca, Spain

[5] Ctr Red Med Regenerat & Terapia Celular Castilla, Barcelona, Spain

[6] Hosp Univ Virgen del Rocio, Serv Hematol, Inst Biomed Sevilla IBIS, Seville, Spain

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2011年 / 17卷 / 02期

关键词：

Murine model; GVHD; Characterization; BONE-MARROW-TRANSPLANTATION; STEM-CELL TRANSPLANTATION; DRY EYE; MANIFESTATION; SURFACE; MODEL;

D O I：

10.1016/j.bbmt.2010.08.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Graft-versus-host disease (GVHD) is the major cause of morbidity and mortality among patients undergoing allogeneic hematopoietic stem cell transplantation. Although animal models have been clearly established for the study of skin, liver, and gut, currently there is no equivalent experiemental model for analyzing ocular involvement, which is rather common, especially among patients diagnosed with chronic GVHD. In the current study we have developed a murine model of ocular GVHD and, for the first time, we describe the histopathologic features involving cornea and limbus, which could play a role in the physiopathology of the disease at the ocular level. Our results represent a major finding that allows us to define a model for evaluating new therapeutic strategies for treating ocular GVHD prior to their use in clinical setting. Biol Blood Marrow Transplant 17: 270-273 (2011) (C) 2011 American Society for Blood and Marrow Transplantation

引用

页码：270 / 273

页数：4

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