Effect of borane source on the enantioselectivity in the enantiopure oxazaborolidine-catalyzed asymmetric borane reduction of ketones

被引：6

作者：

Wang, Xiao ^{[1
]}

Du, Juanjuan ^{[1
]}

Liu, Han ^{[1
]}

Du, Da-Ming ^{[1
]}

Xu, Jiaxi ^{[1
]}

机构：

[1] Peking Univ, BNLMS, Key Lab Bioorgan Chem & Mol Engn, Coll Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China

来源：

HETEROATOM CHEMISTRY | 2007年 / 18卷 / 07期

关键词：

D O I：

10.1002/hc.20370

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The effect of borane source on enantioselectivity in the enantiopure oxazaborolidine-catalyzed asymmetric borane reduction of ketones has been investigated by using (S)-3,1,2-oxazaborobicyclo[3.3.0]octane and (S)-7,3,1,2-thiaxazaborobicyclo[3.3.0]octane as catalysts. The results indicate that the enantioselective order of different borane sources is borane-dimethyl sulfide < borane-N,N-diethylaniline < borane-THF for the asymmetric reduction of a ketone under the same conditions. (c) 2007 Wiley Periodicals, Inc.

引用

页码：740 / 746

页数：7

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