Iron-catalyzed oxidative biaryl cross-couplings via mixed diaryl titanates: significant influence of the order of combining aryl Grignard reagents with titanate

被引：17
作者：
Liu, Kun Ming [1 ]
Wei, Juan [1 ]
Duan, Xin Fang [1 ]
机构：
[1] Beijing Normal Univ, Coll Chem, Beijing 100875, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 22期
关键词：
DOUBLE TRANSMETALATION; TERMINAL ALKYNES; MANGANESE; OXIDANT; SELECTIVITY; METALATION; COMPLEXES; ALKYLZINC; OXYGEN; O-2;
D O I：
10.1039/c5cc00514k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The mixed diaryl titanates were used for the first time to modify the reactivity of two aryl Grignard reagents. Two titanate intermediates, Ar[Ar'Ti(OR)(3)]MgX and Ar'[ArTi(OR)(3)]MgX, formed via alternating the sequence of combining Grignard reagents with ClTi(OR)(3) showed a significant reactivity difference. Taking advantage of such different reactivity, two highly structurally similar aryl groups could be facilely assembled through iron-catalyzed oxidative cross-couplings using oxygen as the oxidant.
引用
收藏
页码：4655 / 4658
页数：4
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