The dry powder inhaler features of the Easyhaler that benefit the management of patients

被引:12
作者
Chrystyn, Henry [1 ]
Lavorini, Federico [2 ]
机构
[1] Inhalat Consultancy Ltd, Tarn House,77 High St, Leeds LS19 7SP, W Yorkshire, England
[2] Careggi Univ Hosp, Dept Expt & Clin Med, Florence, Italy
关键词
Asthma; COPD; Easyhaler; dry powder inhalers; inhaler resistance; inhalation flow; dose emission; OBSTRUCTIVE PULMONARY-DISEASE; METERED-DOSE INHALER; IN-VITRO; BUDESONIDE/FORMOTEROL COMBINATION; ASTHMA; LUNG; SALBUTAMOL; EQUIVALENT; DEPOSITION; DEVICES;
D O I
10.1080/17476348.2020.1721286
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Introduction: Inhaled therapies are likely to continue to dominate asthma and chronic obstructive pulmonary disease treatment. Dry powder inhalers (DPIs) have several advantages over pressurized metered-dose inhaler (pMDIs), that are most frequently marketed world-wide, but often difficult to use. This literature search focus on DPI features, with respect to Easyhaler, that may affect their use and patients' clinical benefit. Areas covered: DPIs are breath-actuated, easy to use, convenient to use, and more environmentally friendly. During inhalation, the formulation in a DPI is disaggregated by a turbulent airflow energy to generate particles with the greatest likelihood of deposition into the airways. The resistance among DPIs varies from low to high and those with high resistance are wrongly considered as difficult to use. Multidose reservoir-type DPIs have been developed to efficiently deliver a wide range of medications, including the fixed-dose combination of budesonide and formoterol. Easyhaler (R) shares a similar shape with pMDIs and, as other DPIs, its performance is unaffected by environmental and storage conditions. Due to Easyhaler internal design, dose emission is consistent irrespective of the inhalation flow used by each patient. Expert opinion: Easyhaler (R) may be considered one of the most convenient inhalers, for daily use, in patients with asthma or COPD.
引用
收藏
页码:345 / 351
页数:7
相关论文
共 41 条
[1]   Effect of maximum inhalation flow and inhaled volume on formoterol drug deposition in-vitro from an Easyhaler® dry powder inhaler [J].
Abadelah, Mohamad ;
Hazim, Firisteh ;
Chrystyn, Henry ;
Bagherisadeghi, Golshan ;
Rahmoune, Hassan ;
Larhrib, Hassan .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2017, 104 :180-187
[2]   The potential of a 2Tone trainer to help patients use their metered-dose inhalers [J].
Al-Showair, Raid A. M. ;
Pearson, Stanley B. ;
Chrystyn, Henry .
CHEST, 2007, 131 (06) :1776-1782
[3]   The Inhalation Characteristics of Patients When They Use Different Dry Powder Inhalers [J].
Azouz, Wahida ;
Chetcuti, Philip ;
Hosker, Harold S. R. ;
Saralaya, Dinesh ;
Stephenson, John ;
Chrystyn, Henry .
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY, 2015, 28 (01) :35-42
[4]   Clarifying the dilemmas about inhalation techniques for dry powder inhalers: integrating science with clinical practice [J].
Azouz, Wahida ;
Chrystyn, Henry .
PRIMARY CARE RESPIRATORY JOURNAL, 2012, 21 (02) :208-213
[5]  
Braido F, 2015, INT J CHRONIC OBSTR, V10, P2601, DOI 10.2147/COPD.S79635
[6]  
Budesonide WO, 2016, EXPERT OPIN PHARMACO, V7, P1023
[7]   Effective delivery of particles with the HandiHaler® dry powder inhalation system over a range of chronic obstructive pulmonary disease severity [J].
Chodosh, S ;
Flanders, JS ;
Kesten, S ;
Serby, CW ;
Hochrainer, D ;
Witek, TJ .
JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG, 2001, 14 (03) :309-315
[8]   Closer to an "Ideal Inhaler' with the Easyhaler® -: An innovative dry powder inhaler [J].
Chrystyn, Henry .
CLINICAL DRUG INVESTIGATION, 2006, 26 (04) :175-183
[9]   Effect of inhalation profile and throat geometry on predicted lung deposition of budesonide and formoterol (BF) in COPD: An in-vitro comparison of Spiromax with Turbuhaler [J].
Chrystyn, Henry ;
Safioti, Guilherme ;
Keegstra, Johan Rene ;
Gopalan, Gokul .
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2015, 491 (1-2) :268-276
[10]   Impact of patients' satisfaction with their inhalers on treatment compliance and health status in COPD [J].
Chrystyn, Henry ;
Small, Mark ;
Milligan, Gary ;
Higgins, Victoria ;
Garcia Gil, Esther ;
Estruch, Jordi .
RESPIRATORY MEDICINE, 2014, 108 (02) :358-365