Microstructure, mechanical properties, and in vitro biocompatibility of spark plasma sintered hydroxyapatite-aluminum oxide-carbon nanotube composite

被引:56
|
作者
Kalmodia, Sushma [1 ]
Goenka, Shilpi [2 ,3 ]
Laha, Tapas [4 ,5 ]
Lahiri, Debrupa [6 ]
Basu, Bikramjit [1 ]
Balani, Kantesh [1 ]
机构
[1] Indian Inst Technol Kanpur, Dept Mat & Met Engn, Kanpur 208016, Uttar Pradesh, India
[2] Punjab Engn Coll, Dept Met Engn, Du Chandigarh 160012, India
[3] Univ Cincinnati, Dept Chem & Mat Engn, Cincinnati, OH 45221 USA
[4] Indian Inst Technol Kharagpur, Dept Met & Mat Engn, Kharagpur 721302, W Bengal, India
[5] Univ Calif Davis, Dept Chem Engn & Mat Sci, Davis, CA 95616 USA
[6] Florida Int Univ, Dept Mech & Mat Engn, Miami, FL 33174 USA
来源
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2010年 / 30卷 / 08期
关键词
Hydroxyapatite (HA); Alumina (Al2O3); Carbon nanotubes (CNTs); Spark plasma sintering (SPS); Fracture toughness; Biocompatibility; CELL-SHAPE; BEHAVIOR; COATINGS; NANOCOMPOSITES; ADHESION;
D O I
10.1016/j.msec.2010.06.009
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
In the present work. HA reinforced with Al2O3 and multiwalled carbon nanotubes (CNTs) is processed using spark plasma sintering (SPS). Vickers micro indentation and nanoindentation of the samples revealed contrary mechanical properties (hardness of 4.0, 6.1, and 4.4 GPa of HA, HA-Al2O3 and HA-Al2O3-CNT samples at bulk scale, while that of 8.0, 9.0, and 7.0 GPa respectively at nanoscale), owing to the difference in the interaction of the indenter with the material at two different length scales. The addition of Al2O3 reinforcement has been shown to enhance the indentation fracture toughness of HA matrix from 1.18 MPa m(1/2) to 2.07 MPa m(1/2). Further CNT reinforcement has increased the fracture toughness to 2.3 times (2.72 MPa m(1/2)). In vitro biocompatibility of CNT reinforced HA-Al2O3 composite has been evaluated using MTT assay on mouse fibroblast L929 cell line. Cell adhesion and proliferation have been characterized using scanning electron microscopy (SEM), and have been quantified using UV spectrophotometer. The combination of cell viability data as well as microscopic observations of cultured surfaces suggests that SPS sintered HA-Al2O3-CNT composites exhibit the ability to promote cell adhesion and proliferation on their surface and prove to be promising new biocompatible materials. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:1162 / 1169
页数:8
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