Comparative analysis of microRNA expression profiles in the colons of specific pathogen-free mice and germ-free mice

被引：4

作者：

Aoki, Ayako ^{[1
,2
]}

Aoki, Reiji ^{[2
]}

Yatagai, Madoka ^{[1
]}

Kawasumi, Toshiyuki ^{[1
]}

机构：

[1] Japan Womens Univ, Fac Human Sci & Design, Dept Food & Nutr, Bunkyo Ku, Tokyo, Japan

[2] NARO Inst Livestock & Grassland Sci, Tsukuba, Ibaraki, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2021年 / 85卷 / 08期

基金：

日本学术振兴会;

关键词：

microbiota; microRNA; colon; CELL DIFFERENTIATION; MIR-150;

D O I：

10.1093/bbb/zbab112

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs play an important role in microbiota-host crosstalk. In this study, we compared microRNA expression in whole colons of specific pathogen-free mice and germ-free mice. Forty-eight microRNAs were differentially expressed by more than 2-fold. Gene ontology analysis of the predicted mRNA targets revealed that the majority of the most significant gene ontology terms were related to GTPases and nerves.

引用

页码：1869 / 1872

页数：4

共 23 条

[1] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[2] The Intestinal Microbiota Affect Central Levels of Brain-Derived Neurotropic Factor and Behavior in Mice [J].

Bercik, Premysl ;

Denou, Emmanuel ;

Collins, Josh ;

Jackson, Wendy ;

Lu, Jun ;

Jury, Jennifer ;

Deng, Yikang ;

Blennerhassett, Patricia ;

Macri, Joseph ;

McCoy, Kathy D. ;

Verdu, Elena F. ;

Collins, Stephen M. .

GASTROENTEROLOGY, 2011, 141 (02) :599-U701

[3]

Dalmasso G, 2011, PLOS ONE, V6, DOI [10.1371/journal.pone.0019293, 10.1371/journal.pone.0023806]

[4] Gut microbiota regulates maturation of the adult enteric nervous system via enteric serotonin networks [J].

De Vedder, Filipe ;

Grasset, Estelle ;

Holm, Louise Manneras ;

Karsenty, Gerard ;

Macpherson, Andrew J. ;

Olofsson, Louise E. ;

Backhed, Fredrik .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (25) :6458-6463

[5] The gut microbiome: Relationships with disease and opportunities for therapy [J].

Durack, Juliana ;

Lynch, Susan V. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2019, 216 (01) :20-40

[6] Small GTPases of the Ras superfamily regulate intestinal epithelial homeostasis and barrier function via common and unique mechanisms [J].

Francisco Citalan-Madrid, Ali ;

Garcia-Ponce, Alexander ;

Vargas-Robles, Hilda ;

Betanzos, Abigail ;

Schnoor, Michael .

TISSUE BARRIERS, 2013, 1 (05)

[7] Antibiotics-induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility [J].

Ge, Xiaolong ;

Ding, Chao ;

Zhao, Wei ;

Xu, Lizhi ;

Tian, Hongliang ;

Gong, Jianfeng ;

Zhu, Minsheng ;

Li, Jieshou ;

Li, Ning .

JOURNAL OF TRANSLATIONAL MEDICINE, 2017, 15

[8] Modulation of microRNA expression in human T-cell development: targeting of NOTCH3 by miR-150 [J].

Ghisi, Margherita ;

Corradin, Alberto ;

Basso, Katia ;

Frasson, Chiara ;

Serafin, Valentina ;

Mukherjee, Subhamoy ;

Mussolin, Lara ;

Ruggero, Katia ;

Bonanno, Laura ;

Guffanti, Alessandro ;

De Bellis, Gianluca ;

Gerosa, Gino ;

Stellin, Giovanni ;

D'Agostino, Donna M. ;

Basso, Giuseppe ;

Bronte, Vincenzo ;

Indraccolo, Stefano ;

Amadori, Alberto ;

Zanovello, Paola .

BLOOD, 2011, 117 (26) :7053-7062

[9] Local-pooled-error test for identifying differentially expressed genes with a small number of replicated microarrays [J].

Jain, N ;

Thatte, J ;

Braciale, T ;

Ley, K ;

O'Connell, M ;

Lee, JK .

BIOINFORMATICS, 2003, 19 (15) :1945-1951

[10] Comprehensive Expression Analyses of Neural Cell-Type-Specific miRNAs Identify New Determinants of the Specification and Maintenance of Neuronal Phenotypes [J].

Jovicic, Ana ;

Roshan, Reema ;

Moisoi, Nicoleta ;

Pradervand, Sylvain ;

Moser, Roger ;

Pillai, Beena ;

Luthi-Carter, Ruth .

JOURNAL OF NEUROSCIENCE, 2013, 33 (12) :5127-5137

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