Light-triggered photodynamic nanomedicines for overcoming localized therapeutic efficacy in cancer treatment

被引：83

作者：

Choi, Jiwoong ^{[1
,2
]}

Sun, In-Cheol ^{[2
]}

Hwang, Hee Sook ^{[3
]}

Yoon, Hong Yeol ^{[2
]}

Kim, Kwangmeyung ^{[1
,2
]}

机构：

[1] Korea Univ, KU KIST Grad Sch Converging Sci & Technol, 145 Anam Ro, Seoul 02841, South Korea

[2] Korea Inst Sci & Technol KIST, Biomed Res Inst, Med Mat Res Ctr, Hwarangno 14 Gil 5, Seoul 02792, South Korea

[3] Dankook Univ, Dept Pharmaceut Engn, Cheonan 31116, South Korea

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2022年 / 186卷

基金：

新加坡国家研究基金会;

关键词：

Light-triggered nanomedicine; Tumor microenvironment; Photodynamic therapy; Photodynamic imaging; Photodynamic immunotherapy; HYALURONIC-ACID NANOPARTICLES; METAL-ORGANIC FRAMEWORKS; IN-VIVO; SINGLET OXYGEN; DRUG-DELIVERY; CERENKOV RADIATION; PRODRUG MICELLES; ANTICANCER DRUG; ENERGY-TRANSFER; CHLORIN E6;

D O I：

10.1016/j.addr.2022.114344

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Photodynamic nanomedicines have significantly enhanced the therapeutic efficacy of photosensitizers (PSs) by overcoming critical limitations of PSs such as poor water solubility and low tumor accumulation. Furthermore, functional photodynamic nanomedicines have enabled overcoming oxygen depletion during photodynamic therapy (PDT) and tissue light penetration limitation by supplying oxygen or upconverting light in targeted tumor tissues, resulting in providing the potential to overcome biological therapeutic barriers of PDT. Nevertheless, their localized therapeutic effects still remain a huddle for the effective treatment of metastatic- or recurrent tumors. Recently, newly designed photodynamic nanomedicines and their combination chemo- or immune checkpoint inhibitor therapy enable the systemic treatment of various metastatic tumors by eliciting antitumor immune responses via immunogenic cell death (ICD). This review introduces recent advances in photodynamic nanomedicines and their applications, focusing on overcoming current limitations. Finally, the challenges and future perspectives of the clinical translation of photodynamic nanomedicines in cancer PDT are discussed. (C) 2022 Elsevier B.V. All rights reserved.

引用

页数：22

共 177 条

[21] Fucoidan-based, tumor-activated nanoplatform for overcoming hypoxia and enhancing photodynamic therapy and antitumor immunity [J].

Chung, Chu-Hung ;

Lu, Kun-Ying ;

Lee, Wei-Cheng ;

Hsu, Wen-Jing ;

Lee, Wen-Fu ;

Dai, Jia-Zih ;

Shueng, Pei-Wei ;

Lin, Cheng-Wei ;

Mi, Fwu-Long .

BIOMATERIALS, 2020, 257

[22] In Vivo Targeted Deep-Tissue Photodynamic Therapy Based on Near-Infrared Light Triggered Upconversion Nanoconstruct [J].

Cui, Sisi ;

Yin, Deyan ;

Chen, Yuqi ;

Di, Yingfeng ;

Chen, Haiyan ;

Ma, Yuxiang ;

Achilefu, Samuel ;

Gu, Yueqing .

ACS NANO, 2013, 7 (01) :676-688

[23] Photodynamic therapy (PDT) of cancer: from local to systemic treatment [J].

Dabrowski, Janusz M. ;

Arnaut, Luis G. .

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2015, 14 (10) :1765-1780

[24] Near-infrared light excited photodynamic anticancer therapy based on UCNP@AIEgen nanocomposite [J].

Ding, Shihui ;

Wu, Wenbo ;

Peng, Tingting ;

Pang, Wen ;

Jiang, Pengfei ;

Zhan, Qiuqiang ;

Qi, Shuhong ;

Wei, Xunbin ;

Gu, Bobo ;

Liu, Bin .

NANOSCALE ADVANCES, 2021, 3 (08) :2325-2333

[25] Photodynamic therapy for cancer [J].

Dolmans, DEJGJ ;

Fukumura, D ;

Jain, RK .

NATURE REVIEWS CANCER, 2003, 3 (05) :380-387

[26]

Dos Santos AF., 2019, J Cancer Metast Treat, V5, P1, DOI DOI 10.20517/2394-4722.2018.83

[27] Enhanced photodynamic therapy for overcoming tumor hypoxia: From microenvironment regulation to photosensitizer innovation [J].

Du, Jianjun ;

Shi, Tiancong ;

Long, Saran ;

Chen, Pengzhong ;

Sun, Wen ;

Fan, Jiangli ;

Peng, Xiaojun .

COORDINATION CHEMISTRY REVIEWS, 2021, 427

[28] Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products [J].

Dumitriu, IE ;

Baruah, P ;

Valentinis, B ;

Voll, RE ;

Herrmann, M ;

Nawroth, PP ;

Arnold, B ;

Bianchi, ME ;

Manfredi, AA ;

Rovere-Querini, P .

JOURNAL OF IMMUNOLOGY, 2005, 174 (12) :7506-7515

[29] A review of cancer immunotherapy: from the past, to the present, to the future [J].

Esfahani, K. ;

Roudaia, L. ;

Buhlaiga, N. ;

Del Rincon, S., V ;

Papneja, N. ;

Miller, W. H., Jr. .

CURRENT ONCOLOGY, 2020, 27 :S87-S97

[30] Enhancing Triple Negative Breast Cancer Immunotherapy by ICG-Templated Self-Assembly of Paclitaxel Nanoparticles [J].

Feng, Bing ;

Niu, Zifei ;

Hou, Bo ;

Zhou, Lei ;

Li, Yaping ;

Yu, Haijun .

ADVANCED FUNCTIONAL MATERIALS, 2020, 30 (06)

← 1 2 3 4 5 6 7 8 9 10 →