Light-triggered photodynamic nanomedicines for overcoming localized therapeutic efficacy in cancer treatment

被引：72
作者：
Choi, Jiwoong [1 ,2 ]
Sun, In-Cheol [2 ]
Hwang, Hee Sook [3 ]
Yoon, Hong Yeol [2 ]
Kim, Kwangmeyung [1 ,2 ]
机构：
[1] Korea Univ, KU KIST Grad Sch Converging Sci & Technol, 145 Anam Ro, Seoul 02841, South Korea
[2] Korea Inst Sci & Technol KIST, Biomed Res Inst, Med Mat Res Ctr, Hwarangno 14 Gil 5, Seoul 02792, South Korea
[3] Dankook Univ, Dept Pharmaceut Engn, Cheonan 31116, South Korea
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2022年 / 186卷
基金：
新加坡国家研究基金会;
关键词：
Light-triggered nanomedicine; Tumor microenvironment; Photodynamic therapy; Photodynamic imaging; Photodynamic immunotherapy; HYALURONIC-ACID NANOPARTICLES; METAL-ORGANIC FRAMEWORKS; IN-VIVO; SINGLET OXYGEN; DRUG-DELIVERY; CERENKOV RADIATION; PRODRUG MICELLES; ANTICANCER DRUG; ENERGY-TRANSFER; CHLORIN E6;
D O I：
10.1016/j.addr.2022.114344
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Photodynamic nanomedicines have significantly enhanced the therapeutic efficacy of photosensitizers (PSs) by overcoming critical limitations of PSs such as poor water solubility and low tumor accumulation. Furthermore, functional photodynamic nanomedicines have enabled overcoming oxygen depletion during photodynamic therapy (PDT) and tissue light penetration limitation by supplying oxygen or upconverting light in targeted tumor tissues, resulting in providing the potential to overcome biological therapeutic barriers of PDT. Nevertheless, their localized therapeutic effects still remain a huddle for the effective treatment of metastatic- or recurrent tumors. Recently, newly designed photodynamic nanomedicines and their combination chemo- or immune checkpoint inhibitor therapy enable the systemic treatment of various metastatic tumors by eliciting antitumor immune responses via immunogenic cell death (ICD). This review introduces recent advances in photodynamic nanomedicines and their applications, focusing on overcoming current limitations. Finally, the challenges and future perspectives of the clinical translation of photodynamic nanomedicines in cancer PDT are discussed. (C) 2022 Elsevier B.V. All rights reserved.
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页数：22
相关论文
共 177 条
  • [21] Fucoidan-based, tumor-activated nanoplatform for overcoming hypoxia and enhancing photodynamic therapy and antitumor immunity
    Chung, Chu-Hung
    Lu, Kun-Ying
    Lee, Wei-Cheng
    Hsu, Wen-Jing
    Lee, Wen-Fu
    Dai, Jia-Zih
    Shueng, Pei-Wei
    Lin, Cheng-Wei
    Mi, Fwu-Long
    [J]. BIOMATERIALS, 2020, 257
  • [22] In Vivo Targeted Deep-Tissue Photodynamic Therapy Based on Near-Infrared Light Triggered Upconversion Nanoconstruct
    Cui, Sisi
    Yin, Deyan
    Chen, Yuqi
    Di, Yingfeng
    Chen, Haiyan
    Ma, Yuxiang
    Achilefu, Samuel
    Gu, Yueqing
    [J]. ACS NANO, 2013, 7 (01) : 676 - 688
  • [23] Photodynamic therapy (PDT) of cancer: from local to systemic treatment
    Dabrowski, Janusz M.
    Arnaut, Luis G.
    [J]. PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2015, 14 (10) : 1765 - 1780
  • [24] Near-infrared light excited photodynamic anticancer therapy based on UCNP@AIEgen nanocomposite
    Ding, Shihui
    Wu, Wenbo
    Peng, Tingting
    Pang, Wen
    Jiang, Pengfei
    Zhan, Qiuqiang
    Qi, Shuhong
    Wei, Xunbin
    Gu, Bobo
    Liu, Bin
    [J]. NANOSCALE ADVANCES, 2021, 3 (08): : 2325 - 2333
  • [25] Photodynamic therapy for cancer
    Dolmans, DEJGJ
    Fukumura, D
    Jain, RK
    [J]. NATURE REVIEWS CANCER, 2003, 3 (05) : 380 - 387
  • [26] Dos Santos A. F., 2019, J CANCER METAS TREAT, V5, DOI DOI 10.20517/2394-4722.2018.83
  • [27] Enhanced photodynamic therapy for overcoming tumor hypoxia: From microenvironment regulation to photosensitizer innovation
    Du, Jianjun
    Shi, Tiancong
    Long, Saran
    Chen, Pengzhong
    Sun, Wen
    Fan, Jiangli
    Peng, Xiaojun
    [J]. COORDINATION CHEMISTRY REVIEWS, 2021, 427
  • [28] Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products
    Dumitriu, IE
    Baruah, P
    Valentinis, B
    Voll, RE
    Herrmann, M
    Nawroth, PP
    Arnold, B
    Bianchi, ME
    Manfredi, AA
    Rovere-Querini, P
    [J]. JOURNAL OF IMMUNOLOGY, 2005, 174 (12) : 7506 - 7515
  • [29] A review of cancer immunotherapy: from the past, to the present, to the future
    Esfahani, K.
    Roudaia, L.
    Buhlaiga, N.
    Del Rincon, S., V
    Papneja, N.
    Miller, W. H., Jr.
    [J]. CURRENT ONCOLOGY, 2020, 27 : S87 - S97
  • [30] Enhancing Triple Negative Breast Cancer Immunotherapy by ICG-Templated Self-Assembly of Paclitaxel Nanoparticles
    Feng, Bing
    Niu, Zifei
    Hou, Bo
    Zhou, Lei
    Li, Yaping
    Yu, Haijun
    [J]. ADVANCED FUNCTIONAL MATERIALS, 2020, 30 (06)
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