Light-triggered photodynamic nanomedicines for overcoming localized therapeutic efficacy in cancer treatment

被引：83

作者：

Choi, Jiwoong ^{[1
,2
]}

Sun, In-Cheol ^{[2
]}

Hwang, Hee Sook ^{[3
]}

Yoon, Hong Yeol ^{[2
]}

Kim, Kwangmeyung ^{[1
,2
]}

机构：

[1] Korea Univ, KU KIST Grad Sch Converging Sci & Technol, 145 Anam Ro, Seoul 02841, South Korea

[2] Korea Inst Sci & Technol KIST, Biomed Res Inst, Med Mat Res Ctr, Hwarangno 14 Gil 5, Seoul 02792, South Korea

[3] Dankook Univ, Dept Pharmaceut Engn, Cheonan 31116, South Korea

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2022年 / 186卷

基金：

新加坡国家研究基金会;

关键词：

Light-triggered nanomedicine; Tumor microenvironment; Photodynamic therapy; Photodynamic imaging; Photodynamic immunotherapy; HYALURONIC-ACID NANOPARTICLES; METAL-ORGANIC FRAMEWORKS; IN-VIVO; SINGLET OXYGEN; DRUG-DELIVERY; CERENKOV RADIATION; PRODRUG MICELLES; ANTICANCER DRUG; ENERGY-TRANSFER; CHLORIN E6;

D O I：

10.1016/j.addr.2022.114344

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Photodynamic nanomedicines have significantly enhanced the therapeutic efficacy of photosensitizers (PSs) by overcoming critical limitations of PSs such as poor water solubility and low tumor accumulation. Furthermore, functional photodynamic nanomedicines have enabled overcoming oxygen depletion during photodynamic therapy (PDT) and tissue light penetration limitation by supplying oxygen or upconverting light in targeted tumor tissues, resulting in providing the potential to overcome biological therapeutic barriers of PDT. Nevertheless, their localized therapeutic effects still remain a huddle for the effective treatment of metastatic- or recurrent tumors. Recently, newly designed photodynamic nanomedicines and their combination chemo- or immune checkpoint inhibitor therapy enable the systemic treatment of various metastatic tumors by eliciting antitumor immune responses via immunogenic cell death (ICD). This review introduces recent advances in photodynamic nanomedicines and their applications, focusing on overcoming current limitations. Finally, the challenges and future perspectives of the clinical translation of photodynamic nanomedicines in cancer PDT are discussed. (C) 2022 Elsevier B.V. All rights reserved.

引用

页数：22

共 177 条

[1] Self-Assembled Peptide- and Protein-Based Nanomaterials for Antitumor Photodynamic and Photothermal Therapy [J].

Abbas, Manzar ;

Zou, Qianli ;

Li, Shukun ;

Yan, Xuehai .

ADVANCED MATERIALS, 2017, 29 (12)

[2] New photosensitizers for photodynamic therapy [J].

Abrahamse, Heidi ;

Hamblin, Michael R. .

BIOCHEMICAL JOURNAL, 2016, 473 :347-364

[3] Light Technology for Efficient and Effective Photodynamic Therapy: A Critical Review [J].

Algorri, Jose Francisco ;

Ochoa, Mario ;

Roldan-Varona, Pablo ;

Rodriguez-Cobo, Luis ;

Miguel Lopez-Higuera, Jose .

CANCERS, 2021, 13 (14)

[4] The role of photodynamic therapy on multidrug resistant breast cancer [J].

Aniogo, Eric Chekwube ;

George, Blassan Plackal Adimuriyil ;

Abrahamse, Heidi .

CANCER CELL INTERNATIONAL, 2019, 19 (1)

[5] Combining surgery and immunotherapy: turning an immunosuppressive effect into a therapeutic opportunity [J].

Bakos, Orneala ;

Lawson, Christine ;

Rouleau, Samuel ;

Tai, Lee-Hwa .

JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2018, 6

[6] In vivo wireless photonic photodynamic therapy [J].

Bansal, Akshaya ;

Yang, Fengyuan ;

Xi, Tian ;

Zhang, Yong ;

Ho, John S. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (07) :1469-1474

[7] Molecular landmarks of tumor hypoxia across cancer types [J].

Bhandari, Vinayak ;

Hoey, Christianne ;

Liu, Lydia Y. ;

Lalonde, Emilie ;

Ray, Jessica ;

Livingstone, Julie ;

Lesurf, Robert ;

Shiah, Yu-Jia ;

Vujcic, Tina ;

Huang, Xiaoyong ;

Espiritu, Shadrielle M. G. ;

Heisler, Lawrence E. ;

Yousif, Fouad ;

Huang, Vincent ;

Yamaguchi, Takafumi N. ;

Yao, Cindy Q. ;

Sabelnykova, Veronica Y. ;

Fraser, Michael ;

Chua, Melvin L. K. ;

van der Kwast, Theodorus ;

Liu, Stanley K. ;

Boutros, Paul C. ;

Bristow, Robert G. .

NATURE GENETICS, 2019, 51 (02) :308-+

[8] Hypericin-mediated photodynamic therapy in combination with Avastin (bevacizumab) improves tumor response by downregulating angiogenic proteins [J].

Bhuvaneswari, Ramaswamy ;

Yuen, Gan Yik ;

Chee, Soo Khee ;

Olivo, Malini .

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES, 2007, 6 (12) :1275-1283

[9] Metronomic photodynamic therapy as a new paradigm for photodynamic therapy: Rationale and preclinical evaluation of technical feasibility for treating malignant brain tumors [J].

Bisland, SK ;

Lilge, L ;

Lin, A ;

Rusnov, R ;

Wilson, BC .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 2004, 80 (01) :22-30

[10] Molecular photosensitisers for two-photon photodynamic therapy [J].

Bolze, F. ;

Jenni, S. ;

Sour, A. ;

Heitz, V. .

CHEMICAL COMMUNICATIONS, 2017, 53 (96) :12857-12877

← 1 2 3 4 5 6 7 8 9 10 →