Zn(II)-isatin-3-thiosemicarbazone complexes with phosphines or diamines for hydrogen storage and anticancer studies

Novel six zinc(II) mixed ligand complexes of isatin-3-thiosemicarbazone (HITC) and phosphines or diamines were successfully prepared. These coordination materials were all diagnosed using C.H.N, molar conductivity, FTIR and H-1, C-13, P-31 NMR measurements. The analyzes indicated that zinc(II) complexes possess a tetrahedral shape and the ligand (ITC) showed only one coordination mode, negatively charged ITC bounded as a bidentate chelate through the exocyclic nitrogen and the negatively charged sulfur atoms. Four complexes were tested as anti-ovarian cancer, and the results demonstrated that these coordination compounds have a high ability to prevent the growth of tumor cells. The value of cell viability was only 3% for [Zn(ITC)(Bipy)]Cl at a concentration of 400 mu M, while it did not exceed 10% for the rest of the tested complexes. Moreover, the hydrogen storage ability of some complexes were examined under different pressures (0-90 bar) at 77 K. The results demonstrate that the complex [Zn2(ITC)(2)mu-(dppm)(2)]Cl-2 is a potential material for storing hydrogen in physical absorption.