Bioinformatics Analysis of Expression Profiles and Prognostic Values of the Signal Transducer and Activator of Transcription Family Genes in Glioma

被引：12

作者：

Ji, Wei ^{[1
,2
]}

Liu, Yuankun ^{[1
]}

Xu, Bin ^{[1
]}

Mei, Jie ^{[1
]}

Cheng, Chao ^{[1
]}

Xiao, Yong ^{[2
]}

Yang, Kun ^{[2
]}

Huang, Weiyi ^{[1
]}

Jiao, Jiantong ^{[1
]}

Liu, Hongyi ^{[2
]}

Shao, Junfei ^{[1
]}

机构：

[1] Nanjing Med Univ, Wuxi Peoples Hosp, Dept Neurosurg, Wuxi, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Nanjing Brain Hosp, Dept Neurosurg, Nanjing, Peoples R China

来源：

FRONTIERS IN GENETICS | 2021年 / 12卷

基金：

中国国家自然科学基金;

关键词：

glioma; signal transducer and activator of transcription; prognosis; The Cancer Genome Atlas; Chinese Glioma Genome Atlas; CELL-PROLIFERATION; IFN-GAMMA; CANCER; GLIOBLASTOMA; STAT3; INVASION; SURVIVAL; INFLAMMATION; TEMOZOLOMIDE; PROGRESSION;

D O I：

10.3389/fgene.2021.625234

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Signal transducer and activator of transcription (STAT) family genes-of which there are seven members: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, and STAT6-have been associated with the progression of multiple cancers. However, their prognostic values in glioma remain unclear. In this study, we systematically investigated the expression, the prognostic value, and the potential mechanism of the STAT family genes in glioma. The expression of STAT1/2/3/5A/6 members were significantly higher and positively correlated with IDH mutations, while the expression of STAT5B was lower and negatively correlated with IDH mutations in glioma. Survival analysis indicated that the upregulation of STAT1/2/3/5A/6 and downregulation of STAT5B expression was associated with poorer overall survival in glioma. Joint effects analysis of STAT1/2/3/5A/5B/6 expression suggested that the prognostic value of the group was more significant than that of each individual gene. Thus, we constructed a risk score model to predict the prognosis of glioma. The receiver operating characteristic curve and calibration curves showed good performance as prognostic indicators in both TCGA (The Cancer Genome Atlas) and the CGGA (Chinese Glioma Genome Atlas) databases. Furthermore, we analyzed the correlation between STAT expression with immune infiltration in glioma. The Protein-protein interaction network and enrichment analysis showed that STAT members and co-expressed genes mainly participated in signal transduction activity, Hepatitis B, the Jak-STAT signaling pathway, transcription factor activity, sequence-specific DNA binding, and the cytokine-mediated signaling pathway in glioma. In summary, our study analyzed the expression, prognostic values, and biological roles of the STAT gene family members in glioma, based on which we developed a new risk score model to predict the prognosis of glioma more precisely.

引用

页数：15

共 63 条

[1] gp130-Mediated Stat3 Activation in Enterocytes Regulates Cell Survival and Cell-Cycle Progression during Colitis-Associated Tumorigenesis [J].

Bollrath, Julia ;

Phesse, Toby J. ;

von Burstin, Vivian A. ;

Putoczki, Tracy ;

Bennecke, Moritz ;

Bateman, Trudie ;

Nebelsiek, Tim ;

Lundgren-May, Therese ;

Canli, Oezge ;

Schwitalla, Sarah ;

Matthews, Vance ;

Schmid, Roland M. ;

Kirchner, Thomas ;

Arkan, Melek C. ;

Ernst, Matthias ;

Greten, Florian R. .

CANCER CELL, 2009, 15 (02) :91-102

[2] Targeting transcription factor STAT3 for cancer prevention and therapy [J].

Chai, Edna Zhi Pei ;

Shanmugam, Muthu K. ;

Arfuso, Frank ;

Dharmarajan, Arunasalam ;

Wang, Chao ;

Kumar, Alan Prem ;

Samy, Ramar Perumal ;

Lim, Lina H. K. ;

Wang, Lingzhi ;

Goh, Boon Cher ;

Ahn, Kwang Seok ;

Hui, Kam Man ;

Sethi, Gautam .

PHARMACOLOGY & THERAPEUTICS, 2016, 162 :86-97

[3] STAT1 negatively regulates hepatocellular carcinoma cell proliferation [J].

Chen, Guofu ;

Wang, Haihe ;

Xie, Shuli ;

Ma, Jian ;

Wang, Guangyi .

ONCOLOGY REPORTS, 2013, 29 (06) :2303-2310

[4] JP3, an antiangiogenic peptide, inhibits growth and metastasis of gastric cancer through TRIM25/SP1/MMP2 axis [J].

Chen, Jun-Jie ;

Ren, Yan-Lin ;

Shu, Chuan-Jun ;

Zhang, Yi ;

Chen, Min-Juan ;

Xu, Jin ;

Li, Jin ;

Li, Ai-Ping ;

Chen, Dong-Yin ;

He, Jing-Dong ;

Shu, Yong-Qian ;

Zhou, Jian-Wei .

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2020, 39 (01)

[5]

Chen Xuan, 2020, Nan Fang Yi Ke Da Xue Xue Bao, V40, P34, DOI 10.12122/j.issn.1673-4254.2020.01.06

[6] A critical role for stat3 signaling in immune tolerance [J].

Cheng, FD ;

Wang, HW ;

Cuenca, A ;

Huang, M ;

Ghansah, T ;

Brayer, J ;

Kerr, WG ;

Takeda, K ;

Akira, S ;

Schoenberger, SP ;

Yu, H ;

Jove, R ;

Sotomayor, EM .

IMMUNITY, 2003, 19 (03) :425-436

[7]

Cheng JM, 2015, J BIOL REG HOMEOS AG, V29, P85

[8] Comprehensive genomic characterization defines human glioblastoma genes and core pathways [J].

Chin, L. ;

Meyerson, M. ;

Aldape, K. ;

Bigner, D. ;

Mikkelsen, T. ;

VandenBerg, S. ;

Kahn, A. ;

Penny, R. ;

Ferguson, M. L. ;

Gerhard, D. S. ;

Getz, G. ;

Brennan, C. ;

Taylor, B. S. ;

Winckler, W. ;

Park, P. ;

Ladanyi, M. ;

Hoadley, K. A. ;

Verhaak, R. G. W. ;

Hayes, D. N. ;

Spellman, Paul T. ;

Absher, D. ;

Weir, B. A. ;

Ding, L. ;

Wheeler, D. ;

Lawrence, M. S. ;

Cibulskis, K. ;

Mardis, E. ;

Zhang, Jinghui ;

Wilson, R. K. ;

Donehower, L. ;

Wheeler, D. A. ;

Purdom, E. ;

Wallis, J. ;

Laird, P. W. ;

Herman, J. G. ;

Schuebel, K. E. ;

Weisenberger, D. J. ;

Baylin, S. B. ;

Schultz, N. ;

Yao, Jun ;

Wiedemeyer, R. ;

Weinstein, J. ;

Sander, C. ;

Gibbs, R. A. ;

Gray, J. ;

Kucherlapati, R. ;

Lander, E. S. ;

Myers, R. M. ;

Perou, C. M. ;

McLendon, Roger .

NATURE, 2008, 455 (7216) :1061-1068

[9] Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway [J].

de la Iglesia, Nuria ;

Konopka, Genevieve ;

Puram, Sidharth V. ;

Chan, Jennifer A. ;

Bachoo, Robert M. ;

You, Mingjian J. ;

Levy, David E. ;

DePinho, Ronald A. ;

Bonni, Azad .

GENES & DEVELOPMENT, 2008, 22 (04) :449-462

[10]

de la Iglesia N, 2009, CURR MOL MED, V9, P580

← 1 2 3 4 5 6 7 →