DNA replication stress: oncogenes in the spotlight

被引：0

作者：

Primo, Luiza M. F. ^{[1
]}

Teixeira, Leonardo K. ^{[1
]}

机构：

[1] Brazilian Natl Canc Ctr INCA, Program Immunol & Tumor Biol, Grp Cell Cycle Control, Rio De Janeiro, RJ, Brazil

来源：

GENETICS AND MOLECULAR BIOLOGY | 2020年 / 43卷 / 01期

关键词：

Cancer; cell cycle; DNA replication; oncogene; replication stress; COMMON FRAGILE SITE; CYCLIN-E DEREGULATION; HUMAN-CELLS; GENOMIC INSTABILITY; DAMAGE RESPONSE; REACTIVE OXYGEN; C-MYC; NUCLEOTIDE-METABOLISM; RAS ONCOGENES; CDC25; PHOSPHATASES;

D O I：

10.1590/1678-4685GMB-2019-0138

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Precise replication of genetic material is essential to maintain genome stability. DNA replication is a tightly regulated process that ensues faithful copies of DNA molecules to daughter cells during each cell cycle. Perturbation of DNA replication may compromise the transmission of genetic information, leading to DNA damage, mutations, and chromosomal rearrangements. DNA replication stress, also referred to as DNA replicative stress, is defined as the slowing or stalling of replication fork progression during DNA synthesis as a result of different insults. Oncogene activation, one hallmark of cancer, is able to disturb numerous cellular processes, including DNA replication. In fact, extensive work has indicated that oncogene-induced replication stress is an important source of genomic instability in human carcinogenesis. In this review, we focus on main oncogenes that induce DNA replication stress, such as RAS, MYC, Cyclin E, MDM2, and BCL-2 among others, and the molecular mechanisms by which these oncogenes interfere with normal DNA replication and promote genomic instability.

引用

页数：14

共 143 条

[1] Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence [J].

Aird, Katherine M. ;

Zhang, Gao ;

Li, Hua ;

Tu, Zhigang ;

Bitler, Benjamin G. ;

Garipov, Azat ;

Wu, Hong ;

Wei, Zhi ;

Wagner, Stephan N. ;

Herlyn, Meenhard ;

Zhang, Rugang .

CELL REPORTS, 2013, 3 (04) :1252-1265

[2] Chromatin replication and epigenome maintenance [J].

Alabert, Constance ;

Groth, Anja .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2012, 13 (03) :153-167

[3] Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression [J].

Aze, Antoine ;

Sannino, Vincenzo ;

Soffientini, Paolo ;

Bachi, Angela ;

Costanzo, Vincenzo .

NATURE CELL BIOLOGY, 2016, 18 (06) :684-+

[4] Identification of Early Replicating Fragile Sites that Contribute to Genome Instability [J].

Barlow, Jacqueline H. ;

Faryabi, Robert B. ;

Callen, Elsa ;

Wong, Nancy ;

Malhowski, Amy ;

Chen, Hua Tang ;

Gutierrez-Cruz, Gustavo ;

Sun, Hong-Wei ;

McKinnon, Peter ;

Wright, George ;

Casellas, Rafael ;

Robbiani, Davide F. ;

Staudt, Louis ;

Fernandez-Capetillo, Oscar ;

Nussenzweig, Andre .

CELL, 2013, 152 (03) :620-632

[5] DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis [J].

Bartkova, J ;

Horejsi, Z ;

Koed, K ;

Krämer, A ;

Tort, F ;

Zieger, K ;

Guldberg, P ;

Sehested, M ;

Nesland, JM ;

Lukas, C ;

Orntoft, T ;

Lukas, J ;

Bartek, J .

NATURE, 2005, 434 (7035) :864-870

[6] Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints [J].

Bartkova, Jirina ;

Rezaei, Nousin ;

Liontos, Michalis ;

Karakaidos, Panagiotis ;

Kletsas, Dimitris ;

Issaeva, Natalia ;

Vassiliou, Leandros-Vassilios F. ;

Kolettas, Evangelos ;

Niforou, Katerina ;

Zoumpourlis, Vassilis C. ;

Takaoka, Munenori ;

Nakagawa, Hiroshi ;

Tort, Frederic ;

Fugger, Kasper ;

Johansson, Fredrik ;

Sehested, Maxwell ;

Andersen, Claus L. ;

Dyrskjot, Lars ;

Orntoft, Torben ;

Lukas, Jiri ;

Kittas, Christos ;

Helleday, Thomas ;

Halazonetis, Thanos D. ;

Bartek, Jiri ;

Gorgoulis, Vassilis G. .

NATURE, 2006, 444 (7119) :633-637

[7] The landscape of somatic copy-number alteration across human cancers [J].

Beroukhim, Rameen ;

Mermel, Craig H. ;

Porter, Dale ;

Wei, Guo ;

Raychaudhuri, Soumya ;

Donovan, Jerry ;

Barretina, Jordi ;

Boehm, Jesse S. ;

Dobson, Jennifer ;

Urashima, Mitsuyoshi ;

Mc Henry, Kevin T. ;

Pinchback, Reid M. ;

Ligon, Azra H. ;

Cho, Yoon-Jae ;

Haery, Leila ;

Greulich, Heidi ;

Reich, Michael ;

Winckler, Wendy ;

Lawrence, Michael S. ;

Weir, Barbara A. ;

Tanaka, Kumiko E. ;

Chiang, Derek Y. ;

Bass, Adam J. ;

Loo, Alice ;

Hoffman, Carter ;

Prensner, John ;

Liefeld, Ted ;

Gao, Qing ;

Yecies, Derek ;

Signoretti, Sabina ;

Maher, Elizabeth ;

Kaye, Frederic J. ;

Sasaki, Hidefumi ;

Tepper, Joel E. ;

Fletcher, Jonathan A. ;

Tabernero, Josep ;

Baselga, Jose ;

Tsao, Ming-Sound ;

Demichelis, Francesca ;

Rubin, Mark A. ;

Janne, Pasi A. ;

Daly, Mark J. ;

Nucera, Carmelo ;

Levine, Ross L. ;

Ebert, Benjamin L. ;

Gabriel, Stacey ;

Rustgi, Anil K. ;

Antonescu, Cristina R. ;

Ladanyi, Marc ;

Letai, Anthony .

NATURE, 2010, 463 (7283) :899-905

[8] Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development [J].

Bester, Assaf C. ;

Roniger, Maayan ;

Oren, Yifat S. ;

Im, Michael M. ;

Sarni, Dan ;

Chaoat, Malka ;

Bensimon, Aaron ;

Zamir, Gideon ;

Shewach, Donna S. ;

Kerem, Batsheva .

CELL, 2011, 145 (03) :435-446

[9] Signatures of mutation and selection in the cancer genome [J].

Bignell, Graham R. ;

Greenman, Chris D. ;

Davies, Helen ;

Butler, Adam P. ;

Edkins, Sarah ;

Andrews, Jenny M. ;

Buck, Gemma ;

Chen, Lina ;

Beare, David ;

Latimer, Calli ;

Widaa, Sara ;

Hinton, Jonathon ;

Fahey, Ciara ;

Fu, Beiyuan ;

Swamy, Sajani ;

Dalgliesh, Gillian L. ;

Teh, Bin T. ;

Deloukas, Panos ;

Yang, Fengtang ;

Campbell, Peter J. ;

Futreal, P. Andrew ;

Stratton, Michael R. .

NATURE, 2010, 463 (7283) :893-U61

[10] Repetitive Fragile Sites: Centromere Satellite DNA as a Source of Genome Instability in Human Diseases [J].

Black, Elizabeth M. ;

Giunta, Simona .

GENES, 2018, 9 (12)

← 1 2 3 4 5 6 7 8 9 10 →