Brain Serotonin Synthesis in Adult Males Characterized by Physical Aggression during Childhood: A 21-Year Longitudinal Study

被引：41

作者：

Booij, Linda ^{[1
]}

Tremblay, Richard E. ^{[2
,3
,4
,5
,6
,7
]}

Leyton, Marco ^{[1
,8
,9
]}

Seguin, Jean R. ^{[6
,7
]}

Vitaro, Frank ^{[6
,10
]}

Gravel, Paul ^{[1
]}

Perreau-Linck, Elisabeth ^{[1
]}

Levesque, Melissa L. ^{[1
]}

Durand, France ^{[1
]}

Diksic, Mirko ^{[8
,9
]}

Turecki, Gustavo ^{[11
]}

Benkelfat, Chawki ^{[1
,8
,9
]}

机构：

[1] McGill Univ, Dept Psychiat, Montreal, PQ, Canada

[2] Univ Montreal, Dept Psychol, Montreal, PQ H3T 1C5, Canada

[3] Univ Montreal, Dept Pediat, Montreal, PQ H3T 1C5, Canada

[4] Univ Coll Dublin, Sch Publ Hlth & Populat Sci, Dublin 2, Ireland

[5] INSERM, U669, Paris, France

[6] Univ Montreal, Hop St Justine, Res Ctr, Montreal, PQ H3T 1C5, Canada

[7] Univ Montreal, Dept Psychiat, Montreal, PQ H3T 1C5, Canada

[8] McGill Univ, Montreal Neurol Inst, Dept Neurol & Neurosurg, Montreal, PQ H3A 2B4, Canada

[9] McGill Univ, Montreal Neurol Inst, McConnell Brain Imaging Ctr, Montreal, PQ H3A 2B4, Canada

[10] Univ Montreal, Sch Psychoeduc, Montreal, PQ H3T 1C5, Canada

[11] McGill Univ, Douglas Hosp, McGill Grp Suicide Studies, Montreal, PQ, Canada

来源：

PLOS ONE | 2010年 / 5卷 / 06期

基金：

加拿大健康研究院;

关键词：

TEMPORAL-LOBE LESIONS; METHYL-L-TRYPTOPHAN; SYNTHESIS CAPACITY; PERSONALITY-DISORDER; ANTISOCIAL-BEHAVIOR; SYNTHESIS RATES; FRONTAL-LOBE; EARLY-ONSET; BOYS; TRAJECTORIES;

D O I：

10.1371/journal.pone.0011255

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Adults exhibiting severe impulsive and aggressive behaviors have multiple indices of low serotonin (5-HT) neurotransmission. It remains unclear though whether low 5-HT mediates the behavior or instead reflects a pre-existing vulnerability trait. Methodology/Principal Findings: In the present study, positron emission tomography with the tracer alpha-[C-11]methyl-L-tryptophan (C-11-AMT) was used to compare 5-HT synthesis capacity in two groups of adult males from a 21-year longitudinal study (mean age +/- SD: 27.1+/-0.7): individuals with a history of childhood-limited high physical aggression (C-LHPA; N = 8) and individuals with normal (low) patterns of physical aggression (LPA; N = 18). The C-LHPA males had significantly lower trapping of C-11-AMT bilaterally in the orbitofrontal cortex and self-reported more impulsiveness. Despite this, in adulthood there were no group differences in plasma tryptophan levels, genotyping, aggression, emotional intelligence, working memory, computerized measures of impulsivity, psychosocial functioning/adjustment, and personal and family history of mood and substance abuse disorders. Conclusions/Significance: These results force a re-examination of the low 5-HT hypothesis as central in the biology of violence. They suggest that low 5-HT does not mediate current behavior and should be considered a vulnerability factor for impulsive-aggressive behavior that may or may not be expressed depending on other biological factors, experience, and environmental support during development.

引用

页数：9

共 69 条

[61] The inhibition of tryptophan hydroxylase, not protein synthesis, reduces the brain trapping of α-methyl-L-tryptophan:: an autoradiographic study [J].