Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers

被引:59
作者
Santhakumar, Abishek Bommannan [1 ]
Kundur, Avinash Reddy [1 ]
Fanning, Kent [2 ]
Netzel, Michael
Stanley, Roger [3 ]
Singh, Indu [1 ]
机构
[1] Griffith Univ, Heart Fdn Res Ctr, Griffith Hlth Inst, Nathan, Qld 4222, Australia
[2] Agri Sci Queensland, Dept Agr Fisheries & Forestry, Coopers Plains, Qld 4108, Australia
[3] Univ Tasmania, Ctr Food Innovat, Launceston, Tas 7250, Australia
关键词
Anthocyanins; Queen-Garnet plum; Platelet activity; Thrombosis; Anti-platelet therapy; HIPPURIC-ACID; ANTIOXIDANT STATUS; URINARY-EXCRETION; OXIDATIVE STRESS; GRAPE JUICE; BLACK TEA; METABOLITES; POLYPHENOLS; INHIBIT; COCOA;
D O I
10.1016/j.jff.2014.10.026
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
The anti-thrombotic properties of an anthocyanin-rich Queen Garnet plum juice (QGPJ) and anthocyanin-free prune juice (PJ) were studied in this randomised, double-blind, crossover trial. Twenty-one healthy subjects (M = 10, F = 11) consumed QGPJ, PJ or placebo, 200 mL/day for 28-days followed by a 2-week wash-out period. Only QGPJ supplementation inhibited platelet aggregation induced by ADP (<5%, P = 0.02), collagen (<2.7%, P < 0.001) and arachidonic acid (<4%, P < 0.001); reduced platelet activation-dependent surface-marker P-selectin expression of activated de-granulated platelets (<17.2%, P = 0.04); prolonged activated-partial thromboplastin clotting time (>2.1 s,P = 0.03); reduced plasma-fibrinogen (<7.5%, P = 0.02) and malondialdehyde levels, a plasma biomarker of oxidative stress (P = 0.016). PJ supplementation increased plasma hippuric acid content (P = 0.018). QGPJ or PJ supplementation did not affect blood cell counts, lipid profile, or inflammation markers. Our findings suggest that QGPJ but not PJ has the potential to significantly attenuate thrombosis by reducing platelet activation/hyper-coagulability and oxidative stress. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:11 / 22
页数:12
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