Nanobubbles for therapeutic delivery: Production, stability and current prospects

被引：52
作者：
Batchelor, Damien V. B. [1 ]
Armistead, Fern J. [1 ]
Ingram, Nicola [2 ]
Peyman, Sally A. [1 ]
Mclaughlan, James R. [2 ,3 ]
Coletta, P. Louise [2 ]
Evans, Stephen D. [1 ]
机构：
[1] Univ Leeds, Mol & Nanoscale Phys Grp, Sch Phys & Astron, Leeds LS2 9JT, W Yorkshire, England
[2] St James Univ Hosp, Wellcome Trust Brenner Bldg, Leeds Inst Med Res, Leeds LS9 7TF, W Yorkshire, England
[3] Univ Leeds, Fac Elect & Elect Engn, Leeds LS2 9JT, W Yorkshire, England
来源：
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE | 2021年 / 54卷 / 54期
基金：
英国工程与自然科学研究理事会; 英国医学研究理事会;
关键词：
Nanobubbles;   Ultrafine bubbles; Ultrasound; Triggered release; Drug delivery  Therapeutic  Theranostic  Chemotherapy  Cancer  Biomedical; CONTRAST-ENHANCED ULTRASOUND; DRUG-DELIVERY; MACROMOLECULAR THERAPEUTICS; MICROBUBBLE POPULATIONS; SILICA NANOPARTICLES; ECHOGENIC LIPOSOMES; POLYMERIC MICELLES; PLGA NANOBUBBLES; TARGETED THERAPY; CANCER-CELLS;
D O I：
10.1016/j.cocis.2021.101456
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Nanobubbles (NBs) have recently garnered widespread attention for their potential use as dual diagnostic and therapeutic agents. Similar to their micron-sized relatives (microbubbles), NBs are shell-stabilized, gas-cored bubbles that in conjunction with ultrasound can be used to increase imaging contrast, as well as provide a mechanism for trigger drug release and increased therapeutic delivery. In this review, we specifically focus on their development as agents to enhance drug delivery, discussing theory, characterization techniques, key formulations and prospects for translation into clinical use.
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页数：24
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