Geriatric Assessment in Older Patients with Acute Myeloid Leukemia

被引：22

作者：

Loh, Kah Poh ^{[1
]}

Klepin, Heidi D. ^{[2
]}

机构：

[1] Univ Rochester, James P Wilmot Canc Inst, Med Ctr, 601 Elmwood Ave,Box 704, Rochester, NY 14642 USA

[2] Wake Forest Baptist Comprehens Canc Ctr, Med Ctr Blvd, Winston Salem, NC 27157 USA

来源：

CANCERS | 2018年 / 10卷 / 07期

关键词：

comprehensive geriatric assessment; older adults; acute myeloid leukemia; RECEIVING INDUCTION CHEMOTHERAPY; ASSESSMENT PREDICTS SURVIVAL; ELDERLY-PATIENTS; DECISION-MAKING; SCREENING TOOLS; EARLY DEATH; ADULTS; CANCER; MORTALITY; THERAPY;

D O I：

10.3390/cancers10070225

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The incidence of acute myeloid leukemia (AML) increases with age, but the outcomes for older adults with AML are poor due to underlying tumor biology, poor tolerance to aggressive treatment, and the physiologic changes of aging. Because of the underlying heterogeneity in health status, treatment decisions are difficult in this population. A geriatric assessment (GA) refers to the use of various validated tools to assess domains that are important in older adults including physical function, cognition, comorbidities, polypharmacy, social support, and nutritional status. In older patients with cancer, a GA can guide treatment decision-making, predict treatment toxicity, and guide supportive care interventions. Compared to solids tumors, there is a relative lack of studies evaluating the use of a GA in older patients with AML. In this review, we will discuss the principles, common domains, feasibility, and benefits of GA, with a focus on older patients with AML that includes practical applications for clinical management.

引用

页数：11

共 56 条

[21] Predicting Chemotherapy Toxicity in Older Adults With Cancer: A Prospective Multicenter Study [J].

Hurria, Arti ;

Togawa, Kayo ;

Mohile, Supriya G. ;

Owusu, Cynthia ;

Klepin, Heidi D. ;

Gross, Cary P. ;

Lichtman, Stuart M. ;

Gajra, Ajeet ;

Bhatia, Smita ;

Katheria, Vani ;

Klapper, Shira ;

Hansen, Kurt ;

Ramani, Rupal ;

Lachs, Mark ;

Wong, F. Lennie ;

Tew, William P. .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (25) :3457-3465

[22] Implementing a Geriatric Assessment in Cooperative Group Clinical Cancer Trials: CALGB 360401 [J].

Hurria, Arti ;

Cirrincione, Constance T. ;

Muss, Hyman B. ;

Kornblith, Alice B. ;

Barry, William ;

Artz, Andrew S. ;

Schmieder, Linda ;

Ansari, Rafat ;

Tew, William P. ;

Weckstein, Douglas ;

Kirshner, Jeffrey ;

Togawa, Kayo ;

Hansen, Kurt ;

Katheria, Vani ;

Stone, Richard ;

Galinsky, Ilene ;

Postiglione, John ;

Cohen, Harvey Jay .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (10) :1290-1296

[23] The impact of comprehensive geriatric assessment interventions on tolerance to chemotherapy in older people [J].

Kalsi, T. ;

Babic-Illman, G. ;

Ross, P. J. ;

Maisey, N. R. ;

Hughes, S. ;

Fields, P. ;

Martin, F. C. ;

Wang, Y. ;

Harari, D. .

BRITISH JOURNAL OF CANCER, 2015, 112 (09) :1435-1444

[24] Multicenter, Randomized, Open-Label, Phase III Trial of Decitabine Versus Patient Choice, With Physician Advice, of Either Supportive Care or Low-Dose Cytarabine for the Treatment of Older Patients With Newly Diagnosed Acute Myeloid Leukemia [J].

Kantarjian, Hagop M. ;

Thomas, Xavier G. ;

Dmoszynska, Anna ;

Wierzbowska, Agnieszka ;

Mazur, Grzegorz ;

Mayer, Jiri ;

Gau, Jyh-Pyng ;

Chou, Wen-Chien ;

Buckstein, Rena ;

Cermak, Jaroslav ;

Kuo, Ching-Yuan ;

Oriol, Albert ;

Ravandi, Farhad ;

Faderl, Stefan ;

Delaunay, Jacques ;

Lysak, Daniel ;

Minden, Mark ;

Arthur, Christopher .

JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (21) :2670-2677

[25] Relevance of a systematic geriatric screening and assessment in older patients with cancer: results of a prospective multicentric study [J].

Kenis, C. ;

Bron, D. ;

Libert, Y. ;

Decoster, L. ;

Van Puyvelde, K. ;

Scalliet, P. ;

Cornette, P. ;

Pepersack, T. ;

Luce, S. ;

Langenaeken, C. ;

Rasschaert, M. ;

Allepaerts, S. ;

Van Rijswijk, R. ;

Milisen, K. ;

Flamaing, J. ;

Lobelle, J-P ;

Wildiers, H. .

ANNALS OF ONCOLOGY, 2013, 24 (05) :1306-1312

[26] Performance of Two Geriatric Screening Tools in Older Patients With Cancer [J].

Kenis, Cindy ;

Decoster, Lore ;

Van Puyvelde, Katrien ;

De Greve, Jacques ;

Conings, Godelieve ;

Milisen, Koen ;

Flamaing, Johan ;

Lobelle, Jean-Pierre ;

Wildiers, Hans .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (01) :19-U94

[27] Effect of Intensive Chemotherapy on Physical, Cognitive, and Emotional Health of Older Adults with Acute Myeloid Leukemia [J].

Klepin, Heidi D. ;

Tooze, Janet A. ;

Pardee, Timothy S. ;

Ellis, Leslie R. ;

Berenzon, Dmitriy ;

Mihalko, Shannon L. ;

Danhauer, Suzanne C. ;

Rao, Arati V. ;

Wildes, Tanya M. ;

Williamson, Jeff D. ;

Powell, Bayard L. ;

Kritchevsky, Stephen B. .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2016, 64 (10) :1988-1995

[28] Elderly Acute Myeloid Leukemia: Assessing Risk [J].

Klepin, Heidi D. .

CURRENT HEMATOLOGIC MALIGNANCY REPORTS, 2015, 10 (02) :118-125

[29] Geriatric assessment predicts survival for older adults receiving induction chemotherapy for acute myelogenous leukemia [J].

Klepin, Heidi D. ;

Geiger, Ann M. ;

Tooze, Janet A. ;

Kritchevsky, Stephen B. ;

Williamson, Jeff D. ;

Pardee, Timothy S. ;

Ellis, Leslie R. ;

Powell, Bayard L. .

BLOOD, 2013, 121 (21) :4287-4294

[30] The Feasibility of Inpatient Geriatric Assessment for Older Adults Receiving Induction Chemotherapy for Acute Myelogenous Leukemia [J].

Klepin, Heidi D. ;

Geiger, Ann M. ;

Tooze, Janet A. ;

Kritchevsky, Stephen B. ;

Williamson, Jeff D. ;

Ellis, Leslie R. ;

Levitan, Denise ;

Pardee, Timothy S. ;

Isom, Scott ;

Powell, Bayard L. .

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2011, 59 (10) :1837-1846

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