Reactivity of a new class of P450 enzyme models

被引：27
|
作者：
Meyer, D [1 ]
Leifels, T [1 ]
Sbaragli, L [1 ]
Woggon, WD [1 ]
机构：
[1] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 338卷 / 01期
关键词：
enzyme models; P450; heme-thiolate proteins; iron porphyrins; catalysis; epoxidation; hydroxylation; N-dealkylation; diol cleavage;
D O I：
10.1016/j.bbrc.2005.07.193
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
P450 enzyme models carrying a SO3- ligand coordinating to iron have been synthesized and characterized. These complexes show characteristics very similar to those of iron-heme cofactors of P450 enzymes. Their reactivity towards different reactions catalyzed by P450 enzymes such as epoxidation of double bonds, hydroxylation of non-activated C-H bonds, N-dealkylation of amines, and cleavage of diols (C-C-bond cleavage) has been investigated. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：372 / 377
页数：6
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