Reactivity of a new class of P450 enzyme models

被引：27
|
作者：
Meyer, D [1 ]
Leifels, T [1 ]
Sbaragli, L [1 ]
Woggon, WD [1 ]
机构：
[1] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 338卷 / 01期
关键词：
enzyme models; P450; heme-thiolate proteins; iron porphyrins; catalysis; epoxidation; hydroxylation; N-dealkylation; diol cleavage;
D O I：
10.1016/j.bbrc.2005.07.193
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
P450 enzyme models carrying a SO3- ligand coordinating to iron have been synthesized and characterized. These complexes show characteristics very similar to those of iron-heme cofactors of P450 enzymes. Their reactivity towards different reactions catalyzed by P450 enzymes such as epoxidation of double bonds, hydroxylation of non-activated C-H bonds, N-dealkylation of amines, and cleavage of diols (C-C-bond cleavage) has been investigated. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：372 / 377
页数：6
相关论文
共 50 条
  • [21] A Compound I Mimic Reveals the Transient Active Species of a Cytochrome P450 Enzyme: Insight into the Stereoselectivity of P450-Catalysed Oxidations
    Suzuki, Kazuto
    Stanfield, Joshua Kyle
    Omura, Keita
    Shisaka, Yuma
    Ariyasu, Shinya
    Kasai, Chie
    Aiba, Yuichiro
    Sugimoto, Hiroshi
    Shoji, Osami
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 62 (13)
  • [22] Insights into Cytochrome P450 Enzyme Catalyzed Defluorination of Aromatic Fluorides
    Zhang, Yi
    Mokkawes, Thirakorn
    de Visser, Sam P.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 62 (42)
  • [23] QSAR models of cytochrome P450 enzyme 1A2 inhibitors using CoMFA, CoMSIA and HQSAR
    Sridhar, J.
    Foroozesh, M.
    Stevens, C. L. Klein
    SAR AND QSAR IN ENVIRONMENTAL RESEARCH, 2011, 22 (7-8) : 681 - 697
  • [24] Measurement of cytochrome P450 and NADPH-cytochrome P450 reductase
    Guengerich, F. Peter
    Martin, Martha V.
    Sohl, Christal D.
    Cheng, Qian
    NATURE PROTOCOLS, 2009, 4 (09) : 1245 - 1251
  • [25] Class II Cytochrome P450 Reductase Governs the Biosynthesis of Alkaloids
    Parage, Claire
    Foureau, Emilien
    Kellner, Franziska
    Burlat, Vincent
    Mahroug, Samira
    Lanoue, Arnaud
    Duge de Bernonville, Thomas
    Arias Londono, Monica
    Carqueijeiro, Ines
    Oudin, Audrey
    Besseau, Sebastien
    Papon, Nicolas
    Glevarec, Gaelle
    Atehortua, Lucia
    Giglioli-Guivarc'h, Nathalie
    St-Pierre, Benoit
    Clastre, Marc
    O'Connor, Sarah E.
    Courdavault, Vincent
    PLANT PHYSIOLOGY, 2016, 172 (03) : 1563 - 1577
  • [26] P450 oxidoreductase deficiency -: A new disorder of steroidogenesis
    Miller, WL
    Huang, NW
    Pandey, AV
    Flück, CE
    Agrawal, V
    TESTICULAR CELL DYNAMICS AND ENDOCRINE SIGNALING, 2005, 1061 : 100 - 108
  • [27] Identification of P450 Candidates Associated with the Biosynthesis of Physalin-Class Compounds in Physalis angulata
    Hua, Congkun
    Xu, Zhengqin
    Tang, Nan
    Xu, Yehan
    Zhang, Yansheng
    Li, Changfu
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (18)
  • [28] New Platform for Cytochrome P450 Reaction Combining in Situ Immobilization on Biopolymer
    Lee, Jae Hyung
    Nam, Dong Heon
    Lee, Sahng Ha
    Park, Jong Hyun
    Park, Si Jae
    Lee, Seung Hwan
    Park, Chan Beum
    Jeong, Ki Jun
    BIOCONJUGATE CHEMISTRY, 2014, 25 (12) : 2101 - 2104
  • [29] Oxygen activation by cytochrome P450 monooxygenase
    Hamdane, Djemel
    Zhang, Haoming
    Hollenberg, Paul
    PHOTOSYNTHESIS RESEARCH, 2008, 98 (1-3) : 657 - 666
  • [30] Calix[6]arene-bismetalloporphyrins as Enzyme Models for P450 V. Catalytic Performance in Epoxidation of Styrene
    李东红
    陈淑华
    赵华明
    ChineseJournalofChemistry, 2003, (06) : 683 - 686
12345