Reactivity of a new class of P450 enzyme models

被引：27

作者：

Meyer, D ^{[1
]}

Leifels, T ^{[1
]}

Sbaragli, L ^{[1
]}

Woggon, WD ^{[1
]}

机构：

[1] Univ Basel, Dept Chem, CH-4056 Basel, Switzerland

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2005年 / 338卷 / 01期

关键词：

enzyme models; P450; heme-thiolate proteins; iron porphyrins; catalysis; epoxidation; hydroxylation; N-dealkylation; diol cleavage;

D O I：

10.1016/j.bbrc.2005.07.193

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

P450 enzyme models carrying a SO3- ligand coordinating to iron have been synthesized and characterized. These complexes show characteristics very similar to those of iron-heme cofactors of P450 enzymes. Their reactivity towards different reactions catalyzed by P450 enzymes such as epoxidation of double bonds, hydroxylation of non-activated C-H bonds, N-dealkylation of amines, and cleavage of diols (C-C-bond cleavage) has been investigated. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：372 / 377

页数：6

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