New approaches and potential treatments for dry age-related macular degeneration

被引：40
作者：
Damico, Francisco Max [1 ]
Gasparin, Fabio [1 ]
Scolari, Mariana Ramos [1 ]
Pedral, Lycia Sampaio [1 ]
Takahashi, Beatriz Sayuri [1 ]
机构：
[1] Univ Sao Paulo, Sch Med, Sao Paulo, Brazil
来源：
ARQUIVOS BRASILEIROS DE OFTALMOLOGIA | 2012年 / 75卷 / 01期
基金：
巴西圣保罗研究基金会;
关键词：
Macular degeneration/drug therapy; Retina; Retinal pigment epithelium; Inflammation; Complement activation; PHOTORECEPTOR DEGENERATION; COMPLEMENT ACTIVATION; RETINAL DEGENERATION; GEOGRAPHIC ATROPHY; GLATIRAMER ACETATE; BRUCHS MEMBRANE; DRUSEN; PATHOGENESIS; DELIVERY; THERAPY;
D O I：
10.1590/S0004-27492012000100016
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Emerging treatments for dry age-related macular degeneration (AMD) and geographic atrophy focus on two strategies that target components involved in physiopathological pathways: prevention of photoreceptors and retinal pigment epithelium loss (neuro-protection induction, oxidative damage prevention, and visual cycle modification) and suppression of inflammation. Neuroprotective drugs, such as ciliary neurotrophic factor, brimonidine tartrate, tandospirone, and anti-amyloid beta antibodies, aim to prevent apoptosis of retinal cells. Oxidative stress and depletion of essential micronutrients are targeted by the Age-Related Eye Disease Study (AREDS) formulation. Visual cycle modulators reduce the activity of the photoreceptors and retinal accumulation of toxic fluorophores and lipofuscin. Eyes with dry age-related macular degeneration present chronic inflammation and potential treatments include corticosteroid and complement inhibition. We review the current concepts and rationale of dry age-related macular degeneration treatment that will most likely include a combination of drugs targeting different pathways involved in the development and progression of age-related macular degeneration.
引用
收藏
页码：71 / 75
页数：5
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