New approaches and potential treatments for dry age-related macular degeneration

被引：41
作者：
Damico, Francisco Max [1 ]
Gasparin, Fabio [1 ]
Scolari, Mariana Ramos [1 ]
Pedral, Lycia Sampaio [1 ]
Takahashi, Beatriz Sayuri [1 ]
机构：
[1] Univ Sao Paulo, Sch Med, Sao Paulo, Brazil
来源：
ARQUIVOS BRASILEIROS DE OFTALMOLOGIA | 2012年 / 75卷 / 01期
基金：
巴西圣保罗研究基金会;
关键词：
Macular degeneration/drug therapy; Retina; Retinal pigment epithelium; Inflammation; Complement activation; PHOTORECEPTOR DEGENERATION; COMPLEMENT ACTIVATION; RETINAL DEGENERATION; GEOGRAPHIC ATROPHY; GLATIRAMER ACETATE; BRUCHS MEMBRANE; DRUSEN; PATHOGENESIS; DELIVERY; THERAPY;
D O I：
10.1590/S0004-27492012000100016
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Emerging treatments for dry age-related macular degeneration (AMD) and geographic atrophy focus on two strategies that target components involved in physiopathological pathways: prevention of photoreceptors and retinal pigment epithelium loss (neuro-protection induction, oxidative damage prevention, and visual cycle modification) and suppression of inflammation. Neuroprotective drugs, such as ciliary neurotrophic factor, brimonidine tartrate, tandospirone, and anti-amyloid beta antibodies, aim to prevent apoptosis of retinal cells. Oxidative stress and depletion of essential micronutrients are targeted by the Age-Related Eye Disease Study (AREDS) formulation. Visual cycle modulators reduce the activity of the photoreceptors and retinal accumulation of toxic fluorophores and lipofuscin. Eyes with dry age-related macular degeneration present chronic inflammation and potential treatments include corticosteroid and complement inhibition. We review the current concepts and rationale of dry age-related macular degeneration treatment that will most likely include a combination of drugs targeting different pathways involved in the development and progression of age-related macular degeneration.
引用
收藏
页码：71 / 75
页数：5
相关论文
共 53 条
[1]   Age-related macular degeneration: Etiology, pathogenesis, and therapeutic strategies [J].
Ambati, J ;
Ambati, BK ;
Yoo, SH ;
Ianchulev, S ;
Adamis, AP .
SURVEY OF OPHTHALMOLOGY, 2003, 48 (03) :257-293
[2]  
[Anonymous], [No title captured]
[3]   Preclinical evaluation of brimonidine [J].
Burke, J ;
Schwartz, M .
SURVEY OF OPHTHALMOLOGY, 1996, 41 :S9-S18
[4]  
Burns R P, 1980, Trans Am Ophthalmol Soc, V78, P206
[5]   Age related macular degeneration and drusen: Neuroinflammation in the retina [J].
Buschini, Elisa ;
Piras, Antonio ;
Nuzzi, Raffaele ;
Vercelli, Alessandro .
PROGRESS IN NEUROBIOLOGY, 2011, 95 (01) :14-25
[6]   Complement Deposition and Microglial Activation in the Outer Retina in Light-Induced Retinopathy: Inhibition by a 5-HT1A Agonist [J].
Collier, Robert J. ;
Wang, Yu ;
Smith, Sherry S. ;
Martin, Elizabeth ;
Ornberg, Richard ;
Rhoades, Kristina ;
Romano, Carmelo .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2011, 52 (11) :8108-8116
[7]   Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration [J].
Ding, Jin-Dong ;
Johnson, Lincoln V. ;
Herrmann, Rolf ;
Farsiu, Sina ;
Smith, Stephanie G. ;
Groelle, Marybeth ;
Mace, Brian E. ;
Sullivan, Patrick ;
Jamison, Jeffrey A. ;
Kelly, Una ;
Harrabi, Ons ;
Bollini, Sangeetha Subbarao ;
Dilley, Jeanette ;
Kobayashi, Dione ;
Kuang, Bing ;
Li, Wenlin ;
Pons, Jaume ;
Lin, John C. ;
Rickman, Catherine Bowes .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (28) :E279-E287
[8]  
Donello JE, 2001, J PHARMACOL EXP THER, V296, P216
[9]   The role of inflammation in the pathogenesis of age-related macular degeneration [J].
Donoso, LA ;
Kim, D ;
Frost, A ;
Callahan, A ;
Hageman, G .
SURVEY OF OPHTHALMOLOGY, 2006, 51 (02) :137-152
[10]   PHOTORECEPTOR DEGENERATION IN INHERITED RETINAL DYSTROPHY DELAYED BY BASIC FIBROBLAST GROWTH-FACTOR [J].
FAKTOROVICH, EG ;
STEINBERG, RH ;
YASUMURA, D ;
MATTHES, MT ;
LAVAIL, MM .
NATURE, 1990, 347 (6288) :83-86
123456