Non-human primate models of SIV infection and CNS neuropathology

被引：23
|
作者：
Williams, Kenneth [1 ]
Lackner, Andrew [2 ]
Mallard, Jaclyn [1 ]
机构：
[1] Boston Coll, Dept Biol, Chestnut Hill, MA 02167 USA
[2] Tulane Natl Primate Res Ctr, Covington, LA USA
来源：
CURRENT OPINION IN VIROLOGY | 2016年 / 19卷
基金：
美国国家卫生研究院;
关键词：
NERVOUS-SYSTEM DISEASE; VIRUS MACAQUE MODEL; RHESUS MACAQUES; ANTIRETROVIRAL THERAPY; CD163(+) MACROPHAGES; HIV; BRAIN; MONKEYS; ENCEPHALITIS; DAMAGE;
D O I：
10.1016/j.coviro.2016.07.012
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Non-human primate models of AIDS and neuroAlDS are the premiere model of HIV infection of the CNS and neuropathogenesis. This review discusses current SIV infection models of neuroAlDS emphasizing findings in the last two years. Consistent in these findings is the interplay between host factors that regulate immune responses to virus and viral replication. Several rapid models of AIDS with consistent CNS pathogenesis exist, each of which modulates by antibody treatment or viruses that cause rapid immune suppression and replicate well in macrophages. Consistent in all of these models are data underscoring the importance of monocyte and macrophage activation, infection and accumulation in the CNS.
引用
收藏
页码：92 / 98
页数：7
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