A case of tizanidine-induced hepatic injury

被引：10

作者：

deGraaf, EM

Oosterveld, M

Tjabbes, T

Stricker, BHC

机构：

[1] INSPECTORATE HLTH CARE, DRUG SAFETY UNIT, NL-2280 HW RIJSWIJK, NETHERLANDS

[2] SOPHIA HOSP, DEPT INTERNAL MED, ZWOLLE, NETHERLANDS

[3] UNIV ROTTERDAM HOSP, DEPT INTERNAL MED 2, ROTTERDAM, NETHERLANDS

来源：

JOURNAL OF HEPATOLOGY | 1996年 / 25卷 / 05期

关键词：

drug-induced hepatic injury; hepatotoxicity; muscle relaxants; tizanidine;

D O I：

10.1016/S0168-8278(96)80252-2

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

The case history is presented of a woman who developed serious liver injury while faking 36 mg tizanidine daily. Other causes of hepatic injury were excluded. Symptoms resolved after discontinuation of tizanidine, and the liver enzyme levels were nearly normal 6 weeks after discontinuation of the drug, Rechallenge with 4 mg tizanidine caused a relapse, The temporal relationship between the symptoms and liver enzyme elevations, the absence of other potential causes, and the reaction to rechallenge, strongly implicate tizanidine as the cause of hepatic injury. As we are not aware of similar case histories, this seems to be the first reported case of tizanidine-induced hepatic injury.

引用

页码：772 / 773

页数：2