Synthesis and biological activity of thiazolo[3′,2′ : 2,3]-as-triazino[5,6-b]indoles and isomeric thiazolo[2′,3′ : 3,4]-as-triazino[5,6-b]indoles

被引：0

作者：

Rastogi, Nisheeth ^{[1
]}

Sethi, Rakesh ^{[2
]}

Varma, Rajendra Singh ^{[3
]}

Tripathi, Diwakar ^{[2
]}

机构：

[1] Lucknow Christian Post Grad Coll, Dept Chem, Lucknow 226018, Uttar Pradesh, India

[2] Sri Jai Narain Post Grad Coll, Dept Chem, Lucknow 226001, Uttar Pradesh, India

[3] Univ Lucknow, Dept Chem, Lucknow 226007, Uttar Pradesh, India

来源：

JOURNAL OF THE INDIAN CHEMICAL SOCIETY | 2008年 / 85卷 / 05期

关键词：

indoles; cyclization; antimicrobial activity; unequivocal synthesis;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

9/7-Bromo-2,3-dihydro-8-methoxy-5H-as-triazino[5,6-b]indole-3-thiones 3a,b on condensation with 4-chlorophenacyl bromide give 9/7-bromo-3-[4-chlorophenylthio]-8-methoxy-5H-as-triazno[5,6-b]indole hydrobromides 4a,b which on PPA catalysed cyclization furnish 6/8-bromo-3-[4-chlorophenyl-7-methoxythiazolo[3',2' : 2,3]-as-triazino[5,6-b]indoles 9a,b and not angular isomeric 6/8-bromo-1-[4-chlorophenyl]-7-methoxythiazolo[2',3' : 3,4]-as-triazino [5,6-b] indoles 6a,b. The unequivocal synthesis of the latter have also been accomplished. The antimicrobial potential of the compounds 6 and 9 have also been evaluated.

引用

页码：513 / 516

页数：4

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