Synthesis of polymeric nanocapsules by radical UV-activated interface-emulsion polymerization

被引：11

作者：

Bazzano, Marco ^{[1
]}

Pisano, Roberto ^{[1
]}

Brelstaff, Jack ^{[2
]}

Spillantini, Maria Grazia ^{[2
]}

Sidoryk-Wegrzynowicz, Marta ^{[2
]}

Rizza, Giancarlo ^{[3
]}

Sangermano, Marco ^{[1
]}

机构：

[1] Politecn Torino, Dept Appl Sci & Technol, Turin, Italy

[2] Univ Cambridge, Dept Clin Neurosci, Clifford Allbutt Bldg, Cambridge, England

[3] Ecole Polytech, Lab Solides Irradies, CEA IRAMIS CNRS, Palaiseau, France

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2016年 / 54卷 / 20期

基金：

英国国家替代、减少和改良动物研究中心;

关键词：

core-shell nanocapsule; curcumin; drug-delivery systems; interface-emulsion polymerization; mini-emulsion; BLOOD-BRAIN-BARRIER; MINIEMULSION POLYMERIZATION; ALZHEIMERS-DISEASE; DRUG-DELIVERY; NANOPARTICLES; CURCUMIN; ENCAPSULATION; INITIATION; TRANSPORT;

D O I：

10.1002/pola.28226

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A new methodology is reported that allows a better control of the synthesis of polymeric core-shell nanocapsules. These nanocapsules were made of biocompatible polymers, obtained from poly(ethylene glycol)diacrylate and poly(ethylene glycol) methyl ether methacrylate, and were used as carrier for curcumin as therapeutic agent. The impact of manufacturing factors (time of sonication, time of UV irradiation, and type of monomer) was investigated in relation to the average size of nanocapsules, their distribution, shape, composition, stability, and their capability to deliver curcumin. We successfully synthesized core-shell nanocapsules in various sizes, ranging from 80 nm to 300 nm, by acting either on the process conditions or on the composition of the monomer mixture. This wide range of sizes makes the method here proposed very promising for the production of nanocarriers. (c) 2016 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 3357-3369

引用

页码：3357 / 3369

页数：13

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