Total synthesis of aspirin-triggered 15-epi-lipoxin A4

被引：26

作者：

Rodríguez, AR ^{[1
]}

Spur, BW ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Dept Cell Biol, SOM, Stratford, NJ 08084 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 35期

关键词：

palladium catalyst; eicosanoids; Katsuki Sharpless reactions; reduction;

D O I：

10.1016/S0040-4039(01)01187-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of aspirin-triggered 15-epi-LXA(4) has been achieved using a chiral pool strategy for the C1-C12 fragment starting from 2-deoxy-D-ribose. Sharpless catalytic AE generated the C15 chiral center with > 98% ee. The stereospecific (Z)-reduction of the conjugated trienyne to the tetraene was achieved with Zn(Cu, Ag) in aq. CH3OH at aq. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6057 / 6060

页数：4

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