Pathophysiological Role of Chymase-Activated Matrix Metalloproteinase-9

被引：11

作者：

Takai, Shinji ^{[1
]}

Jin, Denan ^{[1
]}

机构：

[1] Osaka Med & Pharmaceut Univ, Dept Innovat Med, Osaka 5698686, Japan

来源：

BIOMEDICINES | 2022年 / 10卷 / 10期

关键词：

chymase; matrix metalloproteinase-9; inhibitor; MAST-CELL CHYMASE; ANGIOTENSIN-DEPENDENT PATHWAY; PREVENTS CARDIAC FIBROSIS; TUMOR-NECROSIS-FACTOR; FATTY LIVER-DISEASE; MATRIX METALLOPROTEINASES; MYOCARDIAL-INFARCTION; NONALCOHOLIC STEATOHEPATITIS; EXPERIMENTAL COLITIS; ACUTE-PANCREATITIS;

D O I：

10.3390/biomedicines10102499

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chymase present in mast cells can directly form matrix metalloproteinase (MMP)-9 from proMMP-9. Chymase-activated MMP-9 has been reportedly closely related to the pathogenesis of various diseases, and inflammation-related diseases in particular. Upregulated chymase and MMP-9 have been observed in tissues from patients and animal models of aortic aneurysm, inflammatory gastrointestinal and hepatic diseases, acute pancreatic failure, atopic dermatitis and rheumatoid arthritis. Chymase at these regions is only derived from mast cells, while MMP-9 is derived from macrophages and neutrophils in addition to mast cells. Chymase inhibitors attenuate MMP-9 formation from pro-MMP-9, and ameliorate the development and progression of these disorders, along with reduction in inflammatory cell numbers. MMP-9 activated by chymase might also be involved in angiogenesis in the tumor environment. Development of angiogenesis around several cancers is closely related to the expression of chymase and MMP-9, and postoperative survival curves have revealed that patients with a higher number of chymase positive cells have lower survival rates. In this review, we wanted to clarify the role of chymase-activated MMP-9, which might become an important therapeutic target for various inflammatory disorders.

引用

页数：13

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