Targeting NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome in Cardiovascular Disorders

被引：56
|
作者：
Wang, Zheng [1 ,2 ]
Hu, Wei [3 ]
Lu, Chenxi [1 ]
Ma, Zhiqiang [4 ]
Jiang, Shuai [5 ]
Gu, Chunhu [6 ]
Acuna-Castroviejo, Dario [7 ]
Yang, Yang [1 ]
机构：
[1] Northwest Univ, Fac Life Sci, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, 229 Taibai N Rd, Xian 710069, Shaanxi, Peoples R China
[2] Wuhan Gen Hosp, Peoples Liberat Army, Dept Cardiothorac Surg, Wuhan, Hubei, Peoples R China
[3] Fourth Mil Med Univ, Dept Immunol, Xian, Shaanxi, Peoples R China
[4] Fourth Mil Med Univ, Tangdu Hosp, Dept Thorac Surg, Xian, Shaanxi, Peoples R China
[5] Fourth Mil Med Univ, Dept Aerosp Med, Xian, Shaanxi, Peoples R China
[6] Fourth Mil Med Univ, Xijing Hosp, Dept Cardiovasc Surg, Xian, Shaanxi, Peoples R China
[7] Univ Granada, Biomed Res Ctr, Hlth Sci Technol Pk,Avda Hosp, E-18071 Granada, Spain
来源：
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2018年 / 38卷 / 12期
基金：
中国国家自然科学基金;
关键词：
atherosclerosis; cardiovascular diseases; inflammation; interleukins; myocardial ischemia; ACUTE MYOCARDIAL-INFARCTION; NF-KAPPA-B; THIOREDOXIN-INTERACTING PROTEIN; TISSUE-SPECIFIC EXPRESSION; CORONARY-ARTERY-DISEASE; GENOME-WIDE ASSOCIATION; TOLL-LIKE RECEPTORS; C-REACTIVE PROTEIN; GENE; NDRG2; ISCHEMIA-REPERFUSION;
D O I：
10.1161/ATVBAHA.118.311916
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Inflammation is an important innate immune response to infection or tissue damage. Inflammasomes are involved in the onset and development of inflammation. The NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome is the best-characterized inflammasome. Recent evidence has indicated the importance of the NLRP3 inflammasome in the pathophysiology of cardiovascular disorders. To further understand the roles of the NLRP3 inflammasome in the cardiovascular system, we provide a comprehensive overview and discuss the remaining questions. First, a summary of NLRP3 inflammasome in the cardiovascular system is introduced. Then, the associations between NLRP3 inflammasome and cardiovascular disorders are presented. Finally, we discuss existing problems and potential directions with this issue. The information compiled here summarizes recent progress, thus potentially aiding in the understanding of the NLRP3 inflammasome in cardiovascular disorders, designing experimental and clinical research about the NLRP3 inflammasome, and promoting therapeutics for cardiovascular disorders.
引用
收藏
页码：2765 / 2779
页数：15
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