Antiplatelet therapy after percutaneous coronary intervention (PCI) has been changing in parallel with the development of drug-eluting stents (DES) and antiplatelet agents. The recommendation of dual antiplatelet therapy duration is getting shorter due to the decreased risk of stent thrombosis in new-generation DES, the use of a P2Y(12) inhibitor as a monotherapy, and the increasing prevalence of high bleeding risk patients. Antithrombotic therapy after PCI has also changed due to the introduction of direct oral anticoagulants. Aspirin-free P2Y(12) inhibitor monotherapy is now being evaluated in several prospective studies as a novel strategy of antiplatelet therapy after PCI. This review shows a current status and provides future perspectives for the antiplatelet therapy after PCI.
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Charite, Dept Cardiol, Benjamin Franklin Campus,Hindenburgdamm 30, D-12203 Berlin, Germany
DZHK, Partner Site Berlin, Berlin, GermanyCharite, Dept Cardiol, Benjamin Franklin Campus,Hindenburgdamm 30, D-12203 Berlin, Germany
Staehli, B. E.
Landmesser, U.
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Charite, Dept Cardiol, Benjamin Franklin Campus,Hindenburgdamm 30, D-12203 Berlin, Germany
DZHK, Partner Site Berlin, Berlin, Germany
BIH, Berlin, GermanyCharite, Dept Cardiol, Benjamin Franklin Campus,Hindenburgdamm 30, D-12203 Berlin, Germany
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Univ Sci Philadelphia, Philadelphia Coll Pharm, Philadelphia, PA 19104 USAUniv Sci Philadelphia, Philadelphia Coll Pharm, Philadelphia, PA 19104 USA
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Univ Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5S 1A1, CanadaUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5S 1A1, Canada
Bagai, Akshay
Bhatt, Deepak L.
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Harvard Univ, Brigham & Womens Hosp, Sch Med, Heart & Vasc Ctr, Boston, MA 02115 USAUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5S 1A1, Canada
Bhatt, Deepak L.
Eikelboom, John W.
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McMaster Univ, Populat Hlth Res Inst, Hamilton, ON L8S 4L8, Canada
Hamilton Hlth Sci, Hamilton, ON, CanadaUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5S 1A1, Canada
Eikelboom, John W.
Mancini, G. B. John
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Univ British Columbia, Vancouver Hosp, Vancouver, BC V5Z 1M9, CanadaUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5S 1A1, Canada
Mancini, G. B. John
Cohen, Eric A.
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Univ Toronto, Sunnybrook Hlth Sci Ctr, Schulich Heart Ctr, Div Cardiol,Dept Med, Toronto, ON M5S 1A1, CanadaUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5S 1A1, Canada
Cohen, Eric A.
Vijayaraghavan, Ram
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Rouge Valley Hlth Syst, Div Cardiol, Scarborough, ON, CanadaUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5S 1A1, Canada
Vijayaraghavan, Ram
Cheema, Asim N.
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Univ Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5S 1A1, CanadaUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5S 1A1, Canada
Cheema, Asim N.
Udell, Jacob A.
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Univ Toronto, Toronto Gen Hosp, Peter Munk Cardiac Ctr, Toronto, ON M5S 1A1, Canada
Univ Toronto, Womens Coll Hosp, Toronto, ON M5S 1A1, CanadaUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5S 1A1, Canada
Udell, Jacob A.
Niznick, Joel
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Univ Ottawa, Ottawa, ON K1N 6N5, CanadaUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5S 1A1, Canada
Niznick, Joel
Tanguay, Jean-Francois
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Univ Montreal, Montreal Heart Inst, Montreal, PQ H3C 3J7, CanadaUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5S 1A1, Canada
Tanguay, Jean-Francois
Verma, Subodh
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St Michaels Hosp, Keenen Res Ctr Biomed Sci, Div Cardiac Surg, 30 Bond St, Toronto, ON M5B 1W8, Canada
St Michaels Hosp, Li Ka Shing Knowledge Inst, 30 Bond St, Toronto, ON M5B 1W8, CanadaUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5S 1A1, Canada
Verma, Subodh
Mehta, Shamir R.
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McMaster Univ, Populat Hlth Res Inst, Hamilton, ON L8S 4L8, Canada
Hamilton Hlth Sci, Hamilton, ON, CanadaUniv Toronto, St Michaels Hosp, Terrence Donnelly Heart Ctr, Toronto, ON M5S 1A1, Canada