Stereoselective Barbier-Type Allylations and Propargylations Mediated by CpTiCl3

被引：8

作者：

Lopez-Martinez, Josefa L. ^{[1
]}

Torres-Garcia, Irene ^{[1
]}

Rodriguez-Garcia, Ignacio ^{[1
]}

Munoz-Dorado, Manuel ^{[1
]}

Alvarez-Corral, Miriam ^{[1
]}

机构：

[1] Univ Almeria, Dept Quim Organ, CeiA3, Almeria 04120, Spain

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 02期

关键词：

ASYMMETRIC ALLYLATION; ALDEHYDES; COMPLEXES;

D O I：

10.1021/acs.joc.8b02643

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

CpTiCl2, prepared in situ by manganese reduction of CpTiCl3, is an excellent new system for the Barbier-type allylation and propargylation of carbonyl compounds. It can be used in catalytic amounts when combined with Et3N center dot HBr/TMSBr, which acts as a regenerating system. The high regio- and stereoselectivity shown by this system makes it useful for prenylation and crotylation processes in the synthesis of natural products.

引用

页码：806 / 816

页数：11

共 33 条

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