Hepatoid adenocarcinoma of the stomach: A case report and literature review

被引：16
作者：
Liu, Xiao-Mei [1 ]
Chen, Gui-Qiu [2 ]
Li, Shun-Li [3 ]
Zai, Tian-Shu [4 ]
机构：
[1] PLA, Hosp 208, Clin Dept 461, Dept Pathol, Changchun 130021, Jilin, Peoples R China
[2] Jilin Univ, China Japan Union Hosp, Dept Pathol, Changchun 130033, Jilin, Peoples R China
[3] PLA, Hosp 208, Clin Dept 461, Dept Surg, Changchun 130062, Jilin, Peoples R China
[4] Jilin Univ, Norman Bethune Coll Med, Changchun 130033, Jilin, Peoples R China
来源：
EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2015年 / 9卷 / 06期
关键词：
hepatoid adenocarcinoma; stomach; CLINICOPATHOLOGICAL FEATURES; ALPHA-FETOPROTEIN; GASTRIC-CARCINOMA; DIFFERENTIATION; CANCER;
D O I：
10.3892/etm.2015.2393
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Hepatoid adenocarcinoma (HAC) is a rare form of gastric cancer that has unique clinicopathological features and an extremely poor prognosis. The present case report describes a patient who was referred to the No. 461 Hospital of PLA (Changchun, China) due to nausea and occasional vomiting of acid/water. The patient was diagnosed with gastric signet-ring cell carcinoma and surgery was recommended. A total gastrectomy was performed on the operable lesion. Histopathological analysis revealed that the tumors exhibited two pathological changes: HAC and signet-ring cell carcinoma differentiation. Furthermore, the tumor cells were immunohistochemically positive for alpha-fetoprotein, cytokeratin low/high molecular weight, Cam5.2, cytokeratin 7, p53, epithelial membrane antigen and carcinoembryonic antigen. Previous studies and our experience have suggested that HAC is an aggressive type of adenocarcinoma; however, radical surgery and chemotherapy may positively impact clinical outcomes.
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收藏
页码：2133 / 2136
页数：4
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