A tumor microenvironment dual responsive contrast agent for contrary contrast-magnetic resonance imaging and specific chemotherapy of tumors

被引：12

作者：

Lu, Yudie ^{[1
]}

Feng, Jie ^{[2
]}

Liang, Zhiyu ^{[2
]}

Lu, Xuanyi ^{[1
]}

Guo, Shuai ^{[1
]}

Huang, Lin ^{[1
]}

Xiong, Wei ^{[2
]}

Chen, Sijin ^{[2
]}

Zhou, Huimin ^{[3
]}

Ma, Xuehua ^{[4
]}

Xu, Yikai ^{[2
]}

Qiu, Xiaozhong ^{[3
]}

Wu, Aiguo ^{[4
]}

Chen, Xiaoyuan ^{[5
,6
,7
,8
,9
]}

Shen, Zheyu ^{[1
,2
,3
]}

机构：

[1] Southern Med Univ, Sch Biomed Engn, 1023 Shatai South Rd, Guangzhou 510515, Guangdong, Peoples R China

[2] Southern Med Univ, Nanfang Hosp, Med Imaging Ctr, 1023 Shatai South Rd, Guangzhou 510515, Guangdong, Peoples R China

[3] Southern Med Univ, Sch Basic Med Sci, Guangdong Prov Key Lab Construct & Detect Tissue, 1023 Shatai South Rd, Guangzhou 510515, Guangdong, Peoples R China

[4] Chinese Acad Sci, Cixi Inst Biomed Engn, Ningbo Inst Mat Technol & Engn, CAS Key Lab Magnet Mat & Devices, 1219 Zhongguan West Rd, Ningbo 315201, Zhejiang, Peoples R China

[5] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Diagnost Radiol Surg Chem & Biomol Engn, Singapore 119074, Singapore

[6] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biomed Engn, Singapore 119074, Singapore

[7] Natl Univ Singapore, Fac Engn, Singapore 119074, Singapore

[8] Natl Univ Singapore, Clin Imaging Res Ctr, Ctr Translat Med, Yong Loo Lin Sch Med, Singapore 117599, Singapore

[9] Natl Univ Singapore, NUS Ctr Nanomed, Yong Loo Lin Sch Med, Nanomed Translat Res Program, Singapore 117597, Singapore

来源：

NANOSCALE HORIZONS | 2022年 / 7卷 / 04期

基金：

中国国家自然科学基金;

关键词：

NEPHROGENIC SYSTEMIC FIBROSIS; IRON-OXIDE NANOPARTICLES; INORGANIC NANOPARTICLES; GADOLINIUM; RATS; SIZE; T-1;

D O I：

10.1039/d1nh00632k

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Development of magnetic resonance imaging (MRI) contrast agents (CAs) is still one of the research hotspots due to the inherent limitations of T-1- or T-2-weighted CAs and T-1/T-2 dual-mode CAs. To dramatically enhance the MRI contrast between tumors and normal tissues, we propose a new concept of contrary contrast-MRI (CC-MRI), whose specific definition is that CC-MRI CAs present a positive or negative signal at normal tissues, but show contrary signals at diseased tissues. To realize CC-MRI of tumors, we designed and developed a tumor microenvironment (TME) dual responsive CA (i.e., SA-FeGdNP-DOX@mPEG), which is almost not responsive under normal physiological conditions, but highly responsive to the acidic and reductive TME. Our SA-FeGdNP-DOX@mPEG shows a negative MRI signal under normal physiological conditions due to the high r(2) value (336.9 mM(-1) s(-1)) and high r(2)/r(1) ratio (18.4), but switches to a positive MRI signal in the TME because of the high r(1) value (20.32 mM(-1) s(-1)) and low r(2)/r(1) ratio (7.2). Our TME dual responsive SA-FeGdNP-DOX@mPEG significantly enhanced the contrast of MR images between tumors and livers, and the Delta SNR difference reached 501%. In addition, our SA-FeGdNP-DOX2@mPEG2 with tumor targetability and controlled DOX release responding to the TME was also used for tumor-specific chemotherapy with reduced side effects.

引用

页码：403 / 413

页数：11

共 43 条

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