A novel approach to the synthesis of amino acids based on cobalt bis(dicarbollide)

被引：13

作者：

Lobanova, I. A. ^{[1
]}

Berzina, M. Ya. ^{[1
]}

Sivaev, I. B. ^{[1
]}

Petrovskii, P. V. ^{[1
]}

Bregadze, V. I. ^{[1
]}

机构：

[1] Russian Acad Sci, AN Nesmeyanov Organoelement Cpds Inst, Moscow 119991, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2010年 / 59卷 / 12期

基金：

俄罗斯基础研究基金会;

关键词：

cobalt complexes; carboranes; oxonium compounds; amino acids; tyrosine; boron neutron capture therapy of cancer; NEUTRON-CAPTURE THERAPY; BLOOD-BRAIN-BARRIER; IN-VITRO; TRANSPORTER; EXPRESSION; BORON; CHEMISTRY; LAT1; 3-O-METHYL-6-F-18-FLUORO-L-DOPA; DERIVATIVES;

D O I：

10.1007/s11172-010-0392-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel approach to the synthesis of boron-containing amino acids based on ring opening of cyclic oxonium derivatives of polyhedral boron hydrides under the action of the terminal functional groups of natural amino acids was proposed. This approach was successfully implemented for the synthesis of cobalt bis(dicarbollide) - tyrosine conjugate.

引用

页码：2302 / 2308

页数：7

共 28 条

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