Synthesis of new 8-arylisoquinoline derivatives by application of palladium-catalyzed Suzuki cross-coupling reactions

被引：8

作者：

Andreu, I

Cabedo, N

Fabis, F

Cortes, D

Rault, S

机构：

[1] Univ Caen, Ctr Etudes & Rech Medicament Normandie, UFR Sci Pharmaceut, F-14032 Caen, France

[2] Univ Valencia, Fac Farm, Dept Farmacol, Lab Farmacognosia, E-46100 Valencia, Spain

来源：

TETRAHEDRON | 2005年 / 61卷 / 34期

关键词：

8-bromotetrahydroisoquinoline; Friedel-Crafts cyclization; 8-aryltetrahydroisoquinolines; Suzuki cross-coupling reactions;

D O I：

10.1016/j.tet.2005.06.025

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New 8-(het)aryltetrahydroisoquinolines (10-14), 8-aryltetrahydroisoquinolin-4-ols (15,16), and 8-phenylisoquinolin-4-ol (17), flexible analogues of aporphine, were synthesized in good yields using palladium-catalyzed Suzuki cross-coupling reactions from 8-bromotetrahydroisoquinotin-4-one (6) as a common intermediate. We also describe the synthesis of this novel intermediate through an easy and efficient method, which involved intramolecular Friedel-Crafts cyclization. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：8282 / 8287

页数：6