Different macro- and micro-rheological properties of native porcine respiratory and intestinal mucus

被引：9

作者：

Bokkasam, Harish ^{[1
]}

Ernst, Matthias ^{[2
]}

Guenther, Marco ^{[2
]}

Wagner, Christian ^{[3
]}

Schaefer, Ulrich F. ^{[1
]}

Lehr, Claus-Michael ^{[1
,4
]}

机构：

[1] Univ Saarland, Dept Pharm, D-66123 Saarbrucken, Germany

[2] Univ Appl Sci, Appl Math, Dept Engn Sci, D-66117 Saarbrucken, Germany

[3] Univ Saarland, Dept Phys, D-66123 Saarbrucken, Germany

[4] Helmholtz Ctr Infect Res HZI, Helmholtz Inst Pharmaceut Res Saarland HIPS, D-66123 Saarbrucken, Germany

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2016年 / 510卷 / 01期

关键词：

Mucus; Rheology; Optical tweezer; Inestine; Trachea; Viscoelastic properties; OPTICAL TWEEZERS;

D O I：

10.1016/j.ijpharm.2016.06.035

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim of this study was to investigate the similarities and differences at macro- and microscale in the viscoelastic properties of mucus that covers the epithelia of the intestinal and respiratory tract. Natural mucus was collected from pulmonary and intestinal regions of healthy pigs. Macro-rheological investigations were carried out through conventional plate-plate rheometry. Microrheology was investigated using optical tweezers. Our data revealed significant differences both in macro- and micro-rheological properties between respiratory and intestinal mucus. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：164 / 167

页数：4

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