Asymmetic Organocatalytic 1,3-Dipolar Cycloaddition of Azomethine Ylide to Methyl 2-(2-Nitrophenyl)acrylate for the Synthesis of Diastereoisomers of Spirotryprostatin A

被引：107

作者：

Chang, Mou-Nuo

Wang, Hao

Gong, Liu-Zhu ^{[1
]}

机构：

[1] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230026, Peoples R China

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 09期

关键词：

MAMMALIAN-CELL CYCLE; (-)-SPIROTRYPROSTATIN-B; ESTERS;

D O I：

10.1021/ol200652j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of two diastereomers of spirotryprostatin A has been established starting with an asymmetric 1,3-dipolar cycloaddition of methyl 2-(2-nitrophenyl)acrylate with azomethine ylides catalyzed by a Bronsted acid.

引用

页码：2418 / 2421

页数：4

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