An ionizable lipid toolbox for RNA delivery

被引：316

作者：

Han, Xuexiang ^{[1
]}

Zhang, Hanwen ^{[1
]}

Butowska, Kamila ^{[1
,2
,3
]}

Swingle, Kelsey L. ^{[1
]}

Alameh, Mohamad-Gabriel ^{[4
]}

Weissman, Drew ^{[4
]}

Mitchell, Michael J. ^{[1
,5
,6
,7
,8
]}

机构：

[1] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

[2] Univ Gdansk, Intercoll Fac Biotechnol, Lab Biophys, Abrahama 58, PL-80307 Gdansk, Poland

[3] Med Univ Gdansk, Abrahama 58, PL-80307 Gdansk, Poland

[4] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

[5] Univ Penn, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA

[6] Univ Penn, Perelman Sch Med, Inst Immunol, Philadelphia, PA 19104 USA

[7] Univ Penn, Perelman Sch Med, Cardiovasc Inst, Philadelphia, PA 19104 USA

[8] Univ Penn, Perelman Sch Med, Inst Regenerat Med, Philadelphia, PA 19104 USA

来源：

NATURE COMMUNICATIONS | 2021年 / 12卷 / 01期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

NANOPARTICLE-MEDIATED DELIVERY; IN-VIVO; SIRNA DELIVERY; EFFICIENT DELIVERY; NANOMATERIALS; FORMULATIONS; POTENT; THERAPEUTICS; OPTIMIZATION;

D O I：

10.1038/s41467-021-27493-0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recent years have witnessed incredible growth in RNA therapeutics, which has benefited significantly from decades of research on lipid nanoparticles, specifically its key component-the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development. RNA therapeutics have benefited significantly from decades of research on lipid nanoparticles, specifically its key component-the ionizable lipid. This comment discusses the major ionizable lipid types, and provides perspectives for future development.

引用

页数：6

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