Chromatin as a metabolic organelle: Integrating the cellular flow of carbon with gene expression

被引:3
|
作者
Cheng, Chen [1 ]
Kurdistani, Siavash K. [1 ,2 ,3 ]
机构
[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Biol Chem, Los Angeles, CA 90095 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, David Geffen Sch Med, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Los Angeles, CA 90095 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1016/j.molcel.2021.12.003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Hsieh et al. (2022) reveal that carbon starvation elicits an unexpected compensatory reallocation of histone acetylation to establish an adaptive gene expression program, demonstrating how chromatin may integrate cellular carbon flow via histone acetylation with gene regulation.
引用
收藏
页码:8 / 9
页数:2
相关论文
共 50 条
  • [1] Integrating gene expression and metabolic profiles
    Li, Z
    Chan, C
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (26) : 27124 - 27137
  • [2] Metabolic regulation of chromatin modifications and gene expression
    Schvartzman, Juan Manuel
    Thompson, Craig B.
    Finley, Lydia W. S.
    JOURNAL OF CELL BIOLOGY, 2018, 217 (07): : 2247 - 2259
  • [3] Regulation of chromatin and gene expression by metabolic enzymes and metabolites
    Li, Xinjian
    Egervari, Gabor
    Wang, Yugang
    Berger, Shelley L.
    Lu, Zhimin
    NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2018, 19 (09) : 563 - 578
  • [4] Regulation of chromatin and gene expression by metabolic enzymes and metabolites
    Xinjian Li
    Gabor Egervari
    Yugang Wang
    Shelley L. Berger
    Zhimin Lu
    Nature Reviews Molecular Cell Biology, 2018, 19 : 563 - 578
  • [5] Chromatin -remodeling links metabolic signaling to gene expression
    Morrison, Ashby J.
    MOLECULAR METABOLISM, 2020, 38
  • [6] Metabolic Signaling into Chromatin Modifications in the Regulation of Gene Expression
    Gao, Tian
    Diaz-Hirashi, Zyanya
    Verdeguer, Francisco
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (12)
  • [7] On the Potential for Integrating Gene Expression and Metabolic Flux Data
    Ovacik, Meric A.
    Androulakis, Ioannis P.
    CURRENT BIOINFORMATICS, 2008, 3 (03) : 142 - 148
  • [8] Integrating regulatory DNA sequence and gene expression to predict genome-wide chromatin accessibility across cellular contexts
    Nair, Surag
    Kim, Daniel S.
    Perricone, Jacob
    Kundaje, Anshul
    BIOINFORMATICS, 2019, 35 (14) : I108 - I116
  • [9] Regulation of the cellular prion protein gene expression depends on chromatin conformation
    Cabral, ALB
    Lee, KS
    Martins, VR
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (07) : 5675 - 5682
  • [10] Modeling gene expression using chromatin features in various cellular contexts
    Xianjun Dong
    Melissa C Greven
    Anshul Kundaje
    Sarah Djebali
    James B Brown
    Chao Cheng
    Thomas R Gingeras
    Mark Gerstein
    Roderic Guigó
    Ewan Birney
    Zhiping Weng
    Genome Biology, 13