Saffron; An updated review on biological properties with special focus on cardiovascular effects

被引:118
作者
Ghaffari, Samad [1 ]
Roshanravan, Neda [1 ]
机构
[1] Tabriz Univ Med Sci, Cardiovasc Res Ctr, Tabriz, Iran
关键词
Cardiovascular disease; Saffron; Carotenoids; Antioxidant; CROCUS-SATIVUS-L; TRANS-SODIUM CROCETINATE; OXIDATIVE STRESS; METABOLIC SYNDROME; IN-VITRO; EXPERIMENTAL ATHEROSCLEROSIS; INFLAMMATORY RESPONSE; GARDENIA-JASMINOIDES; SMOOTH-MUSCLE; RISK-FACTOR;
D O I
10.1016/j.biopha.2018.10.031
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objective: Saffron as a natural product has long been used to impede and treat different disorders including cardiovascular disease (CVDs). Stigma is the most principal part of saffron. Various compounds such as carotenoids and flavonoids are the essential components of saffron stigma. The health benefits of saffron have been shown in previous studies; however, there is a lack of comprehensive data on the mechanistic aspects of its cardiovascular-health properties. This current comprehensive review focuses on the medicinal applications of saffron, and then the new findings regarding its cardiovascular-health effects and various cellular and molecular mechanisms of action will be debated. Methods: The literature search of MEDLINE, Embase, PubMed, Google Scholar and Cochrane Library was performed for all comparative studies since 2000-2018 with the limitations of the English language. Results: The results provided new evidence about antioxidant, anti- inflammatory, anti-atherogenic, antiapoptotic, anti-hypertensive, and hypolipidemic effects of saffron. Pharmacological effects of saffron are due to a number of ingredients contained within this spice, including safranal, crocetin and crocins. Conclusions: Our study concludes that saffron with wide range of usefulness in medicine may be the potent candidate in the process of new drug production for the treatment of CVDs.
引用
收藏
页码:21 / 27
页数:7
相关论文
共 101 条
[1]   Biomedical properties of saffron and its potential use in cancer therapy and chemoprevention trials [J].
Abdullaev, FI ;
Espinosa-Aguirre, JJ .
CANCER DETECTION AND PREVENTION, 2004, 28 (06) :426-432
[2]  
Akhoundzadeh B.A., 2008, J MED PLANTS, V7, P1
[3]   Composition of crocins and picrocrocin from Spanish saffron (Crocus sativus L.) [J].
Alonso, GL ;
Salinas, MR ;
Garijo, J ;
Sánchez-Fernández, MA .
JOURNAL OF FOOD QUALITY, 2001, 24 (03) :219-233
[4]  
Amin B, 2015, BIOACTIVE NUTRACEUTICALS AND DIETARY SUPPLEMENTS IN NEUROLOGICAL AND BRAIN DISEASE: PREVENTION AND THERAPY, P319, DOI 10.1016/B978-0-12-411462-3.00033-3
[5]  
[Anonymous], 1998, ZHONGCAOYAO
[6]   National Institutes of Health Hematopoietic Cell Transplantation Late Effects Initiative: The Cardiovascular Disease and Associated Risk Factors Working Group Report [J].
Armenian, Saro H. ;
Chemaitilly, Wassim ;
Chen, Marcus ;
Chow, Eric J. ;
Duncan, Christine N. ;
Jones, Lee W. ;
Pulsipher, Michael A. ;
Remaley, Alan T. ;
Rovo, Alicia ;
Salooja, Nina ;
Battiwalla, Minoo .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2017, 23 (02) :201-210
[7]   Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice [J].
Asai, A ;
Nakano, T ;
Takahashi, M ;
Nagao, A .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2005, 53 (18) :7302-7306
[8]   Potential of Crocus sativus (saffron) and its Constituent, Crocin, as Hypolipidemic and Antioxidant in Rats [J].
Asdaq, Syed Mohammed Basheeruddin ;
Inamdar, Mohammed Naseeruddin .
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, 2010, 162 (02) :358-372
[9]   Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents [J].
Assimopoulou, AN ;
Sinakos, Z ;
Papageorgiou, VP .
PHYTOTHERAPY RESEARCH, 2005, 19 (11) :997-1000
[10]  
Bathaie S Zahra, 2014, Enzymes, V36, P57, DOI 10.1016/B978-0-12-802215-3.00004-5