Diastereoselective alkylation of a newly designed bislactim ether towards the asymmetric synthesis of α-alkylated serines

被引：14

作者：

Sano, S ^{[1
]}

Takebayashi, M ^{[1
]}

Miwa, T ^{[1
]}

Ishii, T ^{[1
]}

Nagao, Y ^{[1
]}

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan

来源：

TETRAHEDRON-ASYMMETRY | 1998年 / 9卷 / 20期

关键词：

D O I：

10.1016/S0957-4166(98)00370-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Diastereoselective alkylation of ethyl (5S)-3,6-diethoxy-2,5-dihydro-5-isopropyl-2-pyrazinecarboxylate (5S)-3 with alkyl halides was investigated by using NaH and n-BuLi. These alkylated products (2R,5S)-4b-d were converted to the corresponding alpha-alkylated serines (S)-6b-d. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3611 / 3614

页数：4

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