Solubility and thermodynamic analysis of sinapic acid in various neat solvents at different temperatures

被引：54

作者：

Shakeel, Faiyaz ^{[1
,2
]}

Haq, Nazrul ^{[1
,2
]}

Raish, Mohammad ^{[2
]}

Anwer, Md. Khalid ^{[3
]}

Al-Shdefat, Ramadan ^{[3
]}

机构：

[1] King Saud Univ, Ctr Excellence Biotechnol Res, POB 2460, Riyadh 11451, Saudi Arabia

[2] King Saud Univ, Coll Pharm, Dept Pharmaceut, POB 2457, Riyadh 11451, Saudi Arabia

[3] Prince Sattam Bin Abdulaziz Univ, Coll Pharm, Dept Pharmaceut, Al Kharj, Saudi Arabia

来源：

JOURNAL OF MOLECULAR LIQUIDS | 2016年 / 222卷

关键词：

Bioactive compound; Dissolution; Sinapic acid; Solubility; Thermodynamics; MAGNESIUM-DL-ASPARTATE; P-TOLUIC ACID; ANTIOXIDANT ACTIVITY; SCAVENGING ACTIVITY; PHENOLIC-ACIDS; WATER; DERIVATIVES; VANILLIN; EXTRACTS;

D O I：

10.1016/j.molliq.2016.07.007

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this research work, the solubilities of sinapic acid (SA) were determined in eleven different neat solvents including water, ethanol, isopropanol (IPA), ethylene glycol (EG), propylene glycol (PG), 1-butanol, 2-butanol, ethyl acetate (EA), dimethyl sulfoxide (DMSO), polyethylene glycol-400 (PEG-400) and Transcutol at five different temperatures (T= 298.15 K to 318.15 K) and atmospheric pressure. Experimental solubilities expressed in mole fraction of SA were correlated well with Apelblat and van't Hoff models. The solubility expressed in mole fraction of SA was recorded highest in DMSO (1.59 x 10(-1) at T= 318.15 K) followed by PEG-400, Transcutol, ethanol, EA, EG, PG, 2-butanol, 1-butanol, IPA and water. The results of thermodynamic analysis indicated an endothermic and entropy-driven dissolution of SA in most of the neat solvents investigated. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：167 / 171

页数：5

共 36 条

[1] Measurement and correlation of solubility of diosmin in four pure solvents and β-cyclodextrin solution at 298.15 K to 333.15 K [J].