The Impact of RNA Interference in Tick Research

被引:3
作者
de la Fuente, Jose [1 ,2 ]
Kocan, Katherine M. [2 ]
机构
[1] Inst Invest Recursos Cineget IREC CSIC UCLM JCCM, SaBio, Ronda de Toledo S-N, Ciudad Real 13005, Spain
[2] Oklahoma State Univ, Ctr Vet Hlth Sci, Dept Vet Pathobiol, Stillwater, OK 74078 USA
来源
PATHOGENS | 2022年 / 11卷 / 08期
关键词
RNAi; tick; vaccine; CRISPR; arthropod; pathogens; DOUBLE-STRANDED-RNA; GENE; PROTEIN; INHIBITION; REPLICATION; SUPPRESSION; EXPRESSION; INDUCTION; CLEAVAGE; SILENCE;
D O I
10.3390/pathogens11080827
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Over the past two decades, RNA interference (RNAi) in ticks, in combination with omics technologies, have greatly advanced the discovery of tick gene and molecular function. While mechanisms of RNAi were initially elucidated in plants, fungi, and nematodes, the classic 2002 study by Aljamali et al. was the first to demonstrate RNAi gene silencing in ticks. Subsequently, applications of RNAi have led to the discovery of genes that impact tick function and tick-host-pathogen interactions. RNAi will continue to lead to the discovery of an array of tick genes and molecules suitable for the development of vaccines and/or pharmacologic approaches for tick control and the prevention of pathogen transmission.
引用
收藏
页数:8
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