Screening of Photosensitizers by Chemiluminescence Monitoring of Formation Dynamics of Singlet Oxygen during Photodynamic Therapy

Finding an efficient photosensitizer is crucial in ensuring a therapeutic effect of photodynamic treatment. Currently, screening of photosensitizers during photodynamic therapy is' achieved by evaluating the total yield of singlet oxygen, (O-1(2)), rather than monitoring the formation dynamics of O-1(2). O-1(2) based chemiluminescence (CL) a suitable Method to directly monitor the generated amount of O-1(2). Herein, the tetraphenylethene-sodium dodecyl sulfonate surfactant -with aggregation induced emission, characteristics can remarkably amplify the intrinsic CL emission from O-1(2) by integrating its micella microenvironment -with a CL energy acceptor effect in a cage-like structure. We present a new luminescence platform for the rapid screening of photosensitizers by monitoring the formation dynamics of O-1(2) during photodynamic therapy. This study will not only be critical in optimizing the irradiation time during photodynamic therapy but also open a new door to the discovery of efficient photosensitizers.